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G17DT Immunogen
go.drugbank.com/drugs/DB04914InvestigationalIt is also in a phase II/III trial for advanced stomach cancer in combination with 5-fluorouracil and cisplatin and in a late phase II trial for advanced colorectal cancer in combination with irinotecan … It is in phase III trials for advanced pancreatic cancer as a monotherapy and in combination with gemcitabine.
Categories: Amino Acids, Peptides, and Proteins, Hormones, Hormone Substitutes, and Hormone AntagonistsSynonyms: G17DT (AN ANTIGASTRIN IMMUNOGEN)Gepotidacin
go.drugbank.com/drugs/DB12134ApprovedInvestigational[L52680] In March 2025, gepotidacin was approved by the FDA for the treatment of uncomplicated urinary tract infections in select patients. … Gepotidacin is a first-in-class triazaacenaphthylene antibacterial targeting bacterial DNA gyrase and topoisomerase IV.[L52685] Its target is similar to that of fluoroquinolone antibacterials - e.g.
Categories: Triazaacenaphthylene Bacterial Type II Topoisomerase InhibitorBlood Transfusion Complications
go.drugbank.com/conditions/DBCOND0086922Synonyms: Dyspnea due to and following transfusion, Dyspnoea due to and following transfusionSimeprevir
go.drugbank.com/drugs/DB06290ApprovedWithdrawnLike all NS3/4A inhibitors, simeprevir is a serine protease inhibitor in similarity to [DB08873] and [DB05521] but is classified as a second generation protease inhibitor. … Simeprevir was approved by the FDA in November 2014 and is marketed under the brand name Olysio as oral tablets.
Categories: Genito Urinary System and Sex Hormones, Gynecological Antiinfectives and AntisepticsPhosphatidyl serine
go.drugbank.com/drugs/DB00144ApprovedNutraceuticalBecause of the potentail cognitive benefits of phosphatidylserine, the substance is sold as a dietary supplement to people who believe they can benefit from an increased intake. … In apoptosis, phosphatidyl serine is transferred to the outer leaflet of the plasma membrane. This is part of the process by which the cell is targeted for phagocytosis.
Marnetegragene autotemcel
go.drugbank.com/drugs/DB17595Approved[L56116, A275467] Allogeneic hematopoietic stem cell transplant is a curative option but is limited by issues such as donor availability, a high incidence of graft-versus-host disease, and graft failure … [L56115, L56116] Marnetegragene autotemcel is indicated for pediatric patients with severe LAD-I lacking an available HLA-matched sibling donor.[L56115]
Exacerbation of asthma
go.drugbank.com/conditions/DBCOND0022084Synonyms: Other and unspecified asthmaNuclear factor NF-kappa-B
go.drugbank.com/bio_entities/BE0004903TargetHumansThe NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. … The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity
Synonyms: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1Venous Thromboembolism
go.drugbank.com/conditions/DBCOND0000676Drugs: Acetylsalicylic acid · Betrixaban · Dabigatran etexilate · Dalteparin · Nadroparin · Rivaroxaban +1 moreSynonyms: Acute embolism and thrombosis of unspecified veinJoint sprains
go.drugbank.com/conditions/DBCOND0101640Drugs: EscinSynonyms: (Sprains and strains NOS) or (sprain: [joint NOS] or [ligament NOS] or [muscle NOS] or [rectus sprain] or [tendon NOS]) or (tendon rupture NOS)