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Mesoridazine
go.drugbank.com/drugs/DB00933ApprovedWithdrawnA phenothiazine antipsychotic with effects similar to chlorpromazine.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesZaleplon
go.drugbank.com/drugs/DB00962ApprovedIllicitZaleplon interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Zaleplon is a schedule IV drug in the United States.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCinacalcet
go.drugbank.com/drugs/DB01012ApprovedInvestigationalCinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesTopotecan
go.drugbank.com/drugs/DB01030ApprovedInvestigationalAn antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP3A InhibitorsProcainamide
go.drugbank.com/drugs/DB01035ApprovedA derivative of procaine with less CNS action.
Synonyms: p-Aminobenzoic diethylaminoethylamide, p-Amino-N-(2-diethylaminoethyl)benzamideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesBenzylpenicillin
go.drugbank.com/drugs/DB01053ApprovedInvestigationalVet approvedBenzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorptio...
Synonyms: PGMixtures: Bicillin A-P Injection Pws, Bicillin A-P Injection PwsAmoxicillin
go.drugbank.com/drugs/DB01060ApprovedInvestigationalVet approvedAmoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin. Amoxicillin was gr...
Mixtures: AMOXICILLINA E ACIDO CLAVULANICO P-CARE, AMOXICILLINA E ACIDO CLAVULANICO P-CARECategories: Cytochrome P-450 CYP2C8 Inhibitors, Cytochrome P-450 Enzyme InhibitorsPrimaquine
go.drugbank.com/drugs/DB01087ApprovedInvestigationalAn aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by tho...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesTolbutamide
go.drugbank.com/drugs/DB01124ApprovedMedications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C18 SubstratesSynonyms: 1-Butyl-3-(p-tolylsulfonyl)urea, 1-p-Toluenesulfonyl-3-butylureaNefazodone
go.drugbank.com/drugs/DB01149ApprovedWithdrawnNefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic i...
Categories: P-glycoprotein inducers, P-glycoprotein inhibitors