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Debrisoquine
go.drugbank.com/drugs/DB04840ApprovedThey are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. … An adrenergic neuron-blocking drug similar in effects to guanethidine. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesTroleandomycin
go.drugbank.com/drugs/DB13179ApprovedA macrolide antibiotic that is similar to erythromycin.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesFusarium oxysporum
go.drugbank.com/drugs/DB10806ApprovedFusarium oxysporum allergenic extract is used in allergenic testing.
Mixtures: Number Ten Mold Mixture, Number Ten Mold MixtureCenobamate
go.drugbank.com/drugs/DB06119ApprovedInvestigationalCenobamate, or YKP-3089, is an antiepileptic drug developed by SK Pharmaceuticals and used to treat partial onset seizures. … [A188442,L10653] The exact mechanism of action has not been described in the literature, though it positively modulates GABA<sub>A</sub> and inhibits voltage gated sodium channels.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersNilotinib
go.drugbank.com/drugs/DB04868ApprovedInvestigationalA Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to treatment with imatinib (Gleevec … Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML).
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: TASIGNA® 150 MG CAPSULASSpectinomycin
go.drugbank.com/drugs/DB00919ApprovedVet approvedWithdrawnIt is active against gram-negative bacteria and used for the treatment of gonorrhea.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 3-RingProducts: Spectro 5% w/v Oral Solution, TROBICIN FOR INJECTION 2 g/vialOsilodrostat
go.drugbank.com/drugs/DB11837ApprovedInvestigationalCushing's disease is often the result of ACTH hypersecretion secondary to a pituitary tumor, and surgical resection of the tumour is generally the treatment of choice. … Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol.
Categories: MATE 1 Inhibitors, Cytochrome P-450 SubstratesOfatumumab
go.drugbank.com/drugs/DB06650ApprovedInvestigational[L12612] Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however, the antigen is not tumour-specific and can also be found in normal B-cells. … Ofatumumab is used as monotherapy or in combination with other medications, depending on the patient profile and previous treatment history.
Products: İNFÜZYONLUK ÇÖZELTİ KONSATRESİ İÇEREN FLAKON (3 ADET), İNFÜZYONLUK ÇÖZELTİ KONSATRESİ İÇEREN FLAKON (1 ADET)Digitoxin
go.drugbank.com/drugs/DB01396ApprovedWithdrawnA cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. … (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexInulin
go.drugbank.com/drugs/DB00638ApprovedInvestigationalNutraceuticalA starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan. … It has been used in physiologic investigation for determination of the rate of glomerular function.
Categories: Compounds used in a research, industrial, or household setting