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Displaying results 3251 - 3260 of 10000 in total
  1. Drug

    Phenylbutyric acid

    go.drugbank.com/drugs/DB06819
    ApprovedInvestigational

    Phenylbutyric acid is a fatty acid and a derivative of [butyric acid] naturally produced by colonic bacteria fermentation. … It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting as a chemical chaperone.

    Categories: Alimentary Tract and Metabolism, sodium phenylbutyrate and ursodoxicoltaurine
  2. Drug

    Anthrax vaccine

    go.drugbank.com/drugs/DB11003
    ApprovedInvestigational

    It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsulated strain of Bacillus anthracis which are grown in a chemically defined protein-free medium. … [L47561] There are currently 2 anthrax vaccines approved by the FDA: BioThrax in August 15, 2016 and CYFENDUS in July 20, 2023.

  3. Target

    E3 ubiquitin ligase TRAF3IP2

    go.drugbank.com/bio_entities/BE0011632
    TargetHumans

    Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). … and MAPkinase pathways (PubMed:19825828)

    Synonyms: Connection to IKK and SAPK/JNK
  4. Target

    E3 ubiquitin-protein ligase CHIP

    go.drugbank.com/bio_entities/BE0021260
    TargetHumans

    Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (PubMed:19567782). … Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256).

    Synonyms: STIP1 homology and U box-containing protein 1
  5. Drug

    Metaraminol

    go.drugbank.com/drugs/DB00610
    Approved

    An adrenergic agonist that acts predominantly at alpha adrenergic receptors and also stimulates the release of norepinephrine.

    Categories: Adrenergic and Dopaminergic Agents
  6. Drug

    Cefotiam

    go.drugbank.com/drugs/DB00229
    Approved

    One of the cephalosporins that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.

  7. Drug

    Aluminium phosphate

    go.drugbank.com/drugs/DB14517
    ApprovedInvestigational

    Categories: Alimentary Tract and Metabolism, Aluminum and magnesium containing antacids
  8. Drug

    Oxymorphone

    go.drugbank.com/drugs/DB01192
    ApprovedVet approved

    An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. … It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092).

    Products: Numorphan Suppository 5mg
  9. Drug

    Avutometinib

    go.drugbank.com/drugs/DB15254
    ApprovedInvestigational

    [A273948] Avutometinib was approved by the US FDA in May 2025 in a co-package alongside [defactinib] (called Avmapki Fakzynja) for the treatment of recurrent KRAS-mutated low-grade serous ovarian cancer … [L53203,L53198] The MAPK pathway is implicated in variety of cancers, playing a key role in tumor cell proliferation, differentiation and survival.

  10. Drug

    Acipimox

    go.drugbank.com/drugs/DB09055
    ApprovedInvestigational

    Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL. … Long-term administration is associated with reduced mortality, but unwanted effects limit its clinical use.

    Categories: Nicotinic Acid and Derivatives