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Rimegepant
go.drugbank.com/drugs/DB12457ApprovedInvestigationaland cardiovascular disease due to their vasoconstrictive properties. … Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsBromfenac
go.drugbank.com/drugs/DB00963ApprovedWithdrawnNon-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver toxicity.[L43942,T239] … Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation.
Zopapogene imadenovec
go.drugbank.com/drugs/DB24672ApprovedInvestigationalFood and Drug Administration (FDA) for the treatment of adults with RRP, receiving full FDA approval on August 15, 2025.[L54081] … [L54081] Zopapogene imadenovec is a non-replicating adenoviral vector–based immunotherapy that expresses a fusion antigen from selected regions of HPV-6/11 proteins to elicit an immune response in RRP.
Synonyms: human cytomegalovirus (CMV) promoter and terminated with a 3' untranslated region and a simian virus 40 (SV40) polyadenylation signal, gorilla adenovirus vector (strain GC46) encoding human papillomavirus (HPV) type 6 and type 11 antigens comprising 11 epitopes derived from regions of the E2, E4, E6, and E7 proteins under control of aOlipudase alfa
go.drugbank.com/drugs/DB12835ApprovedInvestigational[L42740] ASMD is a rare lysosomal storage disease caused by mutations in the SMPD1 gene, leading to a deficiency in acid sphingomyelinase and the abnormal accumulation of the primary ASM substrate, sphingomyelin … [A251600] Olipudase alfa works to hydrolyze sphingomyelin accumulated in body tissues, such as the lungs, liver, spleen, kidneys, and bone marrow.
Ospemifene
go.drugbank.com/drugs/DB04938ApprovedOspemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesRegramostim
go.drugbank.com/drugs/DB05386InvestigationalRegramostim (GM-CSF) is a differentially glycosylated factor produced mainly by activated T cells and macrophages. … Endothelial cells and fibroblasts can also produce GM-CSF after exposure to TNF-α, IL-1, IL-2 and IFN-γ. GM-CSF is found associated with extracellular matrix and in membrane-bound formats too.
Synonyms: GM-CSF (CHO cell)Tannic acid
go.drugbank.com/drugs/DB09372ApprovedInvestigationalTannic acid is a polyphenolic compound. It is a type of the commercially available tannins. It acts as a weak acid. … It is removed and used as medicine. In the old days it was used as antidote against different poisons.
Mixtures: Extrait De FraisesCategories: Compounds used in a research, industrial, or household settingMarnetegragene autotemcel
go.drugbank.com/drugs/DB17595Approved[L56116, A275467] Allogeneic hematopoietic stem cell transplant is a curative option but is limited by issues such as donor availability, a high incidence of graft-versus-host disease, and graft failure … [L56116, A275467] Marnetegragene autotemcel, also known as marne-cel, is an autologous hematopoietic stem cell-based gene therapy created from the patient's own hematopoietic stem cells.
Synonyms: Autologous CD34+ cells transduced ex vivo with a lentiviral vector (Chim-CD18-WPRE) encoding the ITGB2 gene, Hematopoietic stem cells modified with a lentiviral vector containing the CD18 (integrin beta 2) geneDidecyldimethylammonium
go.drugbank.com/drugs/DB04221ApprovedInvestigationalMixtures: Septi-san, VIR-U-CLEAN Disinfectant Cleaning WipesProducts: S D SMW33
go.drugbank.com/drugs/DB16358ExperimentalMW33 is a recombinant fully human antibody to SARS-CoV-2. … [L27411] This antibody injection is currently being investigated against COVID-19 in the clinical trial NCT04533048 (A Clinical Study to Evaluate MW33 Injection).