Search
Indinavir
go.drugbank.com/drugs/DB00224ApprovedInvestigationalA potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsSynonyms: (1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamideChlorhexidine
go.drugbank.com/drugs/DB00878ApprovedInvestigationalVet approvedWithdrawn[A190417] The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings and two biguanide groups joined by a central hexamethylene chain. … Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms.
Synonyms: 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide), N,N'-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamideInternational brands: Prevacare RAvanafil
go.drugbank.com/drugs/DB06237ApprovedAvanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. … [L32113] It first received FDA approval on April 27, 2012,[L32058] with subsequent EMA approval in June 2013.[L32113]
Categories: Phosphodiesterase 5 Inhibitors, Cytochrome P-450 SubstratesSynonyms: (S)-4-(3-Chloro-4-methoxybenzylamino)-2-(2-hydroxymethylpyrrolidin-1-yl)-N-pyrimidin-2-ylmethyl-5-pyrimidinecarboxamideAnastrozole
go.drugbank.com/drugs/DB01217ApprovedInvestigational[L8863] Anastrozole is also related to [exemestane], a steroidal AI, but its non-steroidal nature provides stark advantages including a lack of steroid-associated adverse effects such as weight gain and … Anastrozole is a non-steroidal aromatase inhibitor (AI), similar to [letrozole], used to decrease circulating estrogen levels in the treatment of postmenopausal women with estrogen-responsive breast cancer
Synonyms: α,α,α',α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrileCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsCefoperazone
go.drugbank.com/drugs/DB01329ApprovedInvestigationalWithdrawnCefoperazone is a semisynthetic broad-spectrum cephalosporin proposed to be effective against <i>Pseudomonas</i> infections. … It is a third-generation antiobiotic agent and it is used in the treatment of various bacterial infections caused by susceptible organisms in the body, including respiratory tract infections, peritonitis
Mixtures: PRİMASEF 500 MG IM/IV ENJEKSİYONLUK TOZ İÇEREN FLAKON, 1 ADET, PRİMASEF 1000 MG IM/IV ENJEKSİYONLUK TOZ İÇEREN FLAKON, 1 ADETCategories: Heterocyclic Compounds, 2-RingCefazolin
go.drugbank.com/drugs/DB01327ApprovedInvestigationalA semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Synonyms: (6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidMixtures: CEFAMEZIN 250 MG IM ENJEKTABL TOZ İÇEREN FLAKON, 1 ADET, CEFAMEZIN 500 MG IM ENJEKTABL TOZ İÇEREN FLAKON, 1 ADETOxacillin
go.drugbank.com/drugs/DB00713ApprovedInvestigationalAn antibiotic similar to flucloxacillin used in resistant staphylococci infections.
Synonyms: 5-methyl-3-phenyl-4-isoxazolyl-penicillin, (5-methyl-3-phenyl-4-isoxazolyl)penicillinInternational brands: Staficilin-NRevumenib
go.drugbank.com/drugs/DB18515ApprovedInvestigationalAbnormal gene rearrangements at chromosome locus 11q23, called KMT2A rearrangements or translocations, are present in 5%-10% of patients with acute leukemias and are the sole genetic aberration found in … [L51888] In October of 20225, it was approved for myeloid leukemia patients with nucleophosmin 1 (NPM1) mutations. [L54376]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsSynonyms: Benzamide, n-ethyl-2-((4-(7-((trans-4-((ethylsulfonyl)amino)cyclohexyl)methyl)-2,7-diazaspiro(3.5)non-2-yl)-5-pyrimidinyl)oxy)-5-fluoro-n-(1-methylethyl)-Levothyroxine
go.drugbank.com/drugs/DB00451ApprovedInvestigationaldeiodination (by type I or type II 5′-deiodinases)[A179941] into its active metabolite T<sub>3</sub>. … While T<sub>4</sub> is the major product secreted by the thyroid gland, T<sub>3</sub> exerts the majority of the physiological effects of the thyroid hormones; T<sub>4</sub> and T<sub>3</sub> have a relative
Synonyms: 3,5,3',5'-Tetraiodo-L-thyronine, O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosineMixtures: BITIRON 50 MCG/12.5 MCG TABLET, 100 ADET, L THYROX JOD HEXAL 75/150Cobicistat
go.drugbank.com/drugs/DB09065ApprovedInvestigationalAlthough it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic exposure of coadministered … Increasing systemic exposure of anti-retrovirals (ARVs) without increasing dosage allows for better treatment outcomes and a decreased side effect profile.
Mixtures: REZOLSTA 800 MG/150 MG FİLM KAPLI TABLET, 30 ADET, GENVOYA FILM COATED TABLET 150 MG/150 MG/200 MG/10 MGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Inhibitors