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Displaying results 3301 - 3310 of 10000 in total
  1. Drug

    Tenofovir alafenamide

    go.drugbank.com/drugs/DB09299
    ApprovedInvestigational

    [A178327] Tenofovir alafenamide is indicated to treat chronic hepatitis B,[L6241] treat HIV-1,[L4388,L6277,L6280,L6283] and prevent HIV-1 infections. … [A178219] It has been reported to produce a large antiviral efficacy at doses ten times lower than tenofovir disoproxil.

    Mixtures: GENVOYA FILM COATED TABLET 150 MG/150 MG/200 MG/10 MG, DESCOVY (200/10 MG)Categories: Vitamin B Complex, Cytochrome P-450 Substrates
  2. Drug

    Asunaprevir

    go.drugbank.com/drugs/DB11586
    ApprovedWithdrawn

    It has been shown to have a very high efficacy in dual-combination regimens with daclatasvir in patients chronically infected with HCV genotype 1b. … [A32528] It was developed by Bristol-Myers Squibb Canada and approved by Health Canada on April 22, 2016. The commercialization of asunaprevir was cancelled one year later on October 16, 2017.[L1113]

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: SUNVEPRA 100 MG KAPSÜL, 56 ADET, SUNVEPRA® 100MG CÁPSULAS BLANDAS
  3. Drug

    Benfotiamine

    go.drugbank.com/drugs/DB11748
    ApprovedInvestigationalWithdrawn

    Benfotiamine has been investigated for the treatment and prevention of Diabetic Nephropathy and Diabetes Mellitus, Type 2.

    Categories: Heterocyclic Compounds, 1-Ring, Vitamin B ComplexSynonyms: S-benzoylthiamine monophosphate
  4. Drug

    Indacaterol

    go.drugbank.com/drugs/DB05039
    ApprovedInvestigational

    It was approved by the European Medicines Agency (EMA) on 30 November 2009 and by the FDA on 1 July 2011. It is marketed in Europe as Onbrez and in America as Arcapta Neohaler. … Indacaterol is also a chiral molecule but only the pure R-enantiomer is dispensed.

    Mixtures: ULTIBRO BREEZHALER INHALATION POWDER HARD CAPSULE 110/50 MCG, ATECTURA®BREEZHALER®150/80 MCG POLVO PARA INHALACIÓN CÁPSULA DURACategories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  5. Drug

    Naftidrofuryl

    go.drugbank.com/drugs/DB13588
    Approved

    Categories: Heterocyclic Compounds, 1-Ring, Serotonin 5-HT2 Receptor AntagonistsProducts: Dusodril retard 100 mg - Filmtabletten, PRAXILENE TABLET 200 mg
  6. Drug

    Ticlopidine

    go.drugbank.com/drugs/DB00208
    Approved

    It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. … The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesProducts: TICLID 250 MG TABLET, 30 ADET, TICLOCARD 250 MG FILM KAPLI TABLET, 30 ADET
  7. Pathway

    Acylcarnitine 10-Hydroxydodec-5-enedioylcarnitine

    smpdb.ca/view/SMP0124031
    Metabolic

    10-Hydroxydodec-5-enedioylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, 10-hydroxydodec-5-enedioyl-CoA reacts with L-carnitine to form 10-hydroxydodec-5-enedioylcarnitine.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Solute carrier family 22 member 5
  8. Drug

    Foscarnet

    go.drugbank.com/drugs/DB00529
    ApprovedInvestigational

    An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV.

    Products: FOSCAVIR INFUSION 24 mg/ml, Foscarnet Tillomed 24 mg/ml Infusionslösung
  9. Drug

    Triazolam

    go.drugbank.com/drugs/DB00897
    ApprovedInvestigational

    Internationally, triazolam is a Schedule IV drug under the Convention on Psychotropic Substances.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingProducts: SOMESE® 0.25 MG TABLETAS, TRIALAM ® 0.25 MG/ TABLETA
  10. Drug

    Peginterferon alfa-2a

    go.drugbank.com/drugs/DB00008
    ApprovedInvestigational

    When combined together, Peginterferon alfa-2a and [DB00811] have been shown to achieve a SVR between 36% for genotype 1 and 59% for genotypes 2-6 after 48 weeks of treatment. … Peginterferon alfa-2a is derived from the alfa-2a moeity of recombinant human interferon and acts by binding to human type 1 interferon receptors.

    Categories: Interferon Type I, Treatments for Hepatitis CProducts: PEGASYS 180 MCG/0.5 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ŞIRINGA, 1 ADET, PEGASYS 135 MCG/0.5 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ŞIRINGA, 1 ADET