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Teduglutide
go.drugbank.com/drugs/DB08900ApprovedInvestigationalTeduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. … The significance of this substitution is that teduglutide is longer acting than endogenous GLP-2 as it is more resistant to proteolysis from dipeptidyl peptidase-4. FDA approved on December 21, 2012.
Categories: Glucagon-like Peptide-2 (GLP-2) Agonists, GLP-2 AnalogSynonyms: Gly(2)-GLP-2, (Gly2)GLP-2Sodium oxybate
go.drugbank.com/drugs/DB09072ApprovedInvestigational[L30598] It is a sodium salt of [gamma-Hydroxybutyric acid], an endogenous cerebral inhibitory neurotransmitter [A251445] and a metabolite of the inhibitory neurotransmitter GABA. … [A18723] For safety reasons, sodium oxybate is a controlled substance only available through a restricted program in approved countries.
Products: Natriumoxybat Kalceks 500 mg/ml Lösung zum Einnehmen, Natriumoxybat neuraxpharm 500 mg/ml Lösung zum EinnehmenInterleukin-10
go.drugbank.com/bio_entities/BE0002484TargetHumansMajor immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetram...
Polypeptides: Interleukin-10Synonyms: IL-10Aquaporin-10
go.drugbank.com/bio_entities/BE0018706TransporterHumansAquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:11573934, PubMed:12084581, PubMed:217338...
Polypeptides: Aquaporin-10Synonyms: AQP-10, Aquaglyceroporin-10Oxymetazoline
go.drugbank.com/drugs/DB00935ApprovedInvestigationalOxymetazoline is an imidazole derivative and a potent, direct-acting alpha (α)-adrenergic agonist with affinity to both α<sub>1</sub>- and α<sub>2</sub>-adrenoceptors. … [L15057] In July 2020, the FDA approved the use of an ophthalmic formulation of oxymetazoline (Upneeq) in adults with acquired blepharoptosis, or ptosis, making it the first FDA-approved medical treatment
Synonyms: 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol, 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenolInternational brands: Dristan 12-Hour, Neo-Synephrine 12 Hour SprayEnzalutamide
go.drugbank.com/drugs/DB08899ApprovedInvestigationalCompared to the average time of 10 to 15 years for a drug to go from pre-clinical to clinical studies, enzalutamide was developed relatively rapidly.[A252667] … [L40639] It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.
Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein inhibitorsProducts: XTANDI ® 40 MG, XTANDI® 40 MGMidostaurin
go.drugbank.com/drugs/DB06595ApprovedInvestigationalIt was approved on April 28, 2017 and has shown to increase the overall survival rate in patients with AML as an adjunct therapy along with chemotherapeutic agents. … It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors [A19108].
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: 4'-N-benzoylstaurosporineOrphenadrine
go.drugbank.com/drugs/DB01173ApprovedInvestigationalA muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Mixtures: Norgesic 35 mg/450 mg Tabletten, MYOGESIC-GCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsGemtuzumab ozogamicin
go.drugbank.com/drugs/DB00056ApprovedInvestigationalGemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheamicin per mole of antibody [FDA Label]. … It is also indicated for the treatment of patients aged 2 years and older with CD33-positive AML who have experienced a relapse or who have not responded to initial treatment (refractory) [L941].
Products: MYLOTARG 5 MG IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMADA KULLANILACAK KONSANTRE İÇİN TOZ, 1 FLAKON, MYLOTARG POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 5MG/VIALDoxofylline
go.drugbank.com/drugs/DB09273InvestigationalIn contrast with other xanthine derivatives, doxofylline does not significantly bind to adenosine alpha-1 or alpha-2 receptors and lacks stimulating effects. … Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7.
Mixtures: MUCOFIX 600/200 MG EFERVESAN, 5 ADET, MUCOFIX 600/200 MG EFERVESAN, 10 ADETCategories: Phosphodiesterase 5 Inhibitors, Adrenergic beta-2 Receptor Agonists