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Displaying results 3331 - 3340 of 10000 in total
  1. Drug

    Manidipine

    go.drugbank.com/drugs/DB09238
    ApprovedInvestigationalWithdrawn

    Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.

    Mixtures: VIVACE 30/10MG TABLETTEN, VIVACE 30/10MG TABLETTENCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 Inhibitors
  2. Drug

    Cobimetinib

    go.drugbank.com/drugs/DB05239
    ApprovedInvestigational

    Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsProducts: COTELLIC® (COBIMETINIB) 20 MG TABLETAS RECUBIERTAS, COTELLIC FILM-COATED TABLET 20 MG
  3. Drug

    Mercaptopurine

    go.drugbank.com/drugs/DB01033
    ApprovedInvestigational

    An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission...

    Categories: Heterocyclic Compounds, 2-Ring, OAT3/SLC22A8 Substrates with a Narrow Therapeutic IndexSynonyms: 6 MP, 6-MP
  4. Drug

    Pegaspargase

    go.drugbank.com/drugs/DB00059
    ApprovedInvestigational

    Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia … [A103,A255912,L44667] Pegaspargase has the same mechanism of action as [L-asparaginase] derived from _Escherichia coli_, a previously developed enzyme used for the treatment of acute lymphoblastic

    Categories: Compounds used in a research, industrial, or household settingSynonyms: PEG-L-Asparaginase, Peg/L-asparaginase
  5. Drug

    Pergolide

    go.drugbank.com/drugs/DB01186
    ApprovedVet approvedWithdrawn

    It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. … Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease.

    Categories: Serotonin 5-HT2 Receptor Agonists, Cytochrome P-450 CYP3A InhibitorsProducts: PERGOLID-NEURAX 1 MG, PERGOLID-NEURAX 0.25 MG
  6. Drug

    Nicotinamide

    go.drugbank.com/drugs/DB02701
    ApprovedInvestigational

    An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra.

    Mixtures: SANASOL 150 ML SURUP, Multivitamin with 1.0 mg FluorideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Inhibitors
  7. Drug

    Plasma protein fraction (human)

    go.drugbank.com/drugs/DB13968
    ApprovedInvestigational

    The composition of PPFh should be 5% of protein from which 83% should consist of albumin and no more of 17% should be globulin. … It is also stated that no more than 1% of the total protein should be gamma globulin.[L2260] PPFh is a sterile, frozen solution of solvent/detergent treated human plasma.

    Mixtures: Varitect CP 25 I.E./ml InfusionslösungProducts: PLASMANATE - 5% (50 ML VIAL), PLASMANATE - 5% ( 250 ML VIAL )
  8. Drug

    Saquinavir

    go.drugbank.com/drugs/DB01232
    ApprovedInvestigational

    Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. … [A214382] While its efficacy was initially limited by exceptionally poor oral bioavailability (approximately 4%),[L3450] its current indications require the co-administration of ritonavir - a potent enzyme

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsProducts: SAQUINAVIR 500 MG TABLETAS., SAQUINAVIR 500 MG TABLETA RECUBIERTA
  9. Drug

    Mosapride

    go.drugbank.com/drugs/DB11675
    Investigational

    Mosapride is under investigation for the treatment and prevention of Postoperative Ileus and Gastric Peroral Endoscopic Pyloromyotomy (G-POEM). … Mosapride has been investigated for the treatment and diagnostic of Constipation, Type 2 Diabetes, Functional Dyspepsia, Functional Constipation, and Epigastric Pain Syndrome, among others.

    Mixtures: GASPRID-S, BONDIGEST COMPLEX® TABLETASCategories: Heterocyclic Compounds, 1-Ring
  10. Target

    5'-nucleotidase

    go.drugbank.com/bio_entities/BE0001096
    TargetEnzymeHumans

    Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587, PubMed:344...

    Polypeptides: 5'-nucleotidaseSynonyms: 5'-NT, 5'-deoxynucleotidase