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Displaying results 3341 - 3350 of 4188 in total
  1. Drug

    Itacitinib

    go.drugbank.com/drugs/DB12154
    Investigational

    Itacitinib has been used in trials studying the treatment of Melanoma, Carcinoma, Metastatic Cancer, Endometrial Cancer, and B-cell Malignancies, among others.

  2. Target

    L-lactate dehydrogenase A chain

    go.drugbank.com/bio_entities/BE0000425
    TargetHumans

    Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)

    Synonyms: Cell proliferation-inducing gene 19 protein
  3. Target

    Transcription factor p65

    go.drugbank.com/bio_entities/BE0005551
    TargetHumans

    Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. … Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression.

    Synonyms: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
  4. Target

    Ubiquitin-conjugating enzyme E2 T

    go.drugbank.com/bio_entities/BE0019778
    TargetHumans

    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fan...

    Synonyms: Cell proliferation-inducing gene 50 protein
  5. Drug

    Triamcinolone

    go.drugbank.com/drugs/DB00620
    ApprovedInvestigationalVet approved

    [L8249] Triamcinolone is more commonly seen in the forms triamcinolone hexacetonide, triamcinolone acetonide, and triamcinolone diacetate.

  6. Drug

    Afamelanotide

    go.drugbank.com/drugs/DB04931
    Approved

    [L9092] Despite its relatively recent approval, afamelanotide has been available for use as an orphan drug in both the US and EU since 2008.[L9122,L9125]

  7. Drug

    Mangafodipir

    go.drugbank.com/drugs/DB06796
    ApprovedInvestigationalWithdrawn

    Teslascan has been removed from the Drug Product List by FDA in 2003, and withdrawn from the European market in 2012.

  8. Drug

    Siplizumab

    go.drugbank.com/drugs/DB06371
    Investigational

  9. Drug

    Radgocitabine

    go.drugbank.com/drugs/DB11667
    Investigational

    2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine has been used in trials studying the treatment of Advanced Colorectal Cancer.

  10. Drug

    Onartuzumab

    go.drugbank.com/drugs/DB11746
    Investigational

    Onartuzumab has been used in trials studying the treatment of Neoplasms, Lung Cancer, Glioblastoma, Gastric Cancer, and Colorectal Cancer, among others.