Transcription factor p65

BE0005551ProteinHumansRELA

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many... It is acted on by 16 drugs in DrugBank.

Gene name
RELA
UniProtKB entry
Q04206Swiss-Prot
Cellular location
Nucleus
Residues / weight
551 residues · 60,219 Da
Also known as
NFKB3 · Nuclear factor NF-kappa-B p65 subunit · Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3

Resolves to

Protein
UniProtQ04206UniProt nameTF65_HUMAN
Gene
HGNCHGNC:9955NCBI Gene5970GeneCardsRELA
Pharmacology
IUPHAR/GtoPdb3280KEGGhsa:5970
Structure
PDB1NFIPDB2LSPPDB2O61
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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56GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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79+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transcription factor p65, how selective are they, and which programs against it are still in active trials?

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