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Displaying results 3341 - 3350 of 10000 in total
  1. Drug

    Pomalidomide

    go.drugbank.com/drugs/DB08910
    ApprovedInvestigational

    Pomalidomide, an analogue of thalidomide, is an immunomodulatory antineoplastic agent. FDA approved on February 8, 2013.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexProducts: POMALYST® 4 MG, POMALYST ® 1 MG
  2. Drug

    Formaldehyde

    go.drugbank.com/drugs/DB03843
    ApprovedVet approved

    In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. … Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)

    Categories: Compounds used in a research, industrial, or household setting
  3. Drug

    Zilganersen

    go.drugbank.com/drugs/DB18161
    ApprovedInvestigational

    [L64096] Alexander disease is caused by variants in the *GFAP* gene that lead to overproduction and toxic accumulation of GFAP in astrocytes, and dysfunction in astrocytes can over time damage neurons … [L64096] The FDA approved zilganersen on September 3, 2026 for the treatment of Alexander disease in pediatric and adult patients, making it the first and only disease-modifying treatment for the condition

  4. Pathway

    Acylcarnitine 3-Hydroxydecanoylcarnitine

    smpdb.ca/view/SMP0123308
    Metabolic

    Once in the matrix, 3-hydroxydecanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form 3-hydroxydecanoyl-CoA and L-carnitine … Acetyl-CoA can go on to enter the TCA cycle, or it can react with L-carnitine to form L-acetylcarnitine in a reaction catalyzed by Carnitine O-acetyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-acetyltransferase, Carnitine O-palmitoyltransferase 2, mitochondrial
  5. Pathway

    Acylcarnitine Octacosanoylcarnitine

    smpdb.ca/view/SMP0123315
    Metabolic

    Once in the matrix, octacosanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form octacosanoyl-CoA and L-carnitine. … Acetyl-CoA can go on to enter the TCA cycle, or it can react with L-carnitine to form L-acetylcarnitine in a reaction catalyzed by Carnitine O-acetyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-acetyltransferase, Carnitine O-palmitoyltransferase 2, mitochondrial
  6. Pathway

    Acylcarnitine Nonacosanoylcarnitine

    smpdb.ca/view/SMP0123316
    Metabolic

    Once in the matrix, Nonacosanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form Nonacosanoyl-CoA and L-carnitine. … Acetyl-CoA can go on to enter the TCA cycle, or it can react with L-carnitine to form L-acetylcarnitine in a reaction catalyzed by Carnitine O-acetyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-acetyltransferase, Carnitine O-palmitoyltransferase 2, mitochondrial
  7. Pathway

    Acylcarnitine (2S,3R)-3-Hydroxy-2-methylbutanoylcarnitine

    smpdb.ca/view/SMP0123317
    Metabolic

    This reaction is catalyzed by carnitine O-palmitoyltransferase. This enzyme resides in the mitochondrial outer membrane. … Once in the matrix, (2S,3R)-3-hydroxy-2-methylbutanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form (2S,3R)-3-hydroxy

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-acetyltransferase, Carnitine O-palmitoyltransferase 2, mitochondrial
  8. Pathway

    Acylcarnitine 3-Hydroxy-2-methylbutanoylcarnitine

    smpdb.ca/view/SMP0123318
    Metabolic

    This reaction is catalyzed by carnitine O-palmitoyltransferase. This enzyme resides in the mitochondrial outer membrane. … Once in the matrix, 3-hydroxy-2-methylbutanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form 3-hydroxy-2-methylbutanoyl-CoA

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-acetyltransferase, Carnitine O-palmitoyltransferase 2, mitochondrial
  9. Pathway

    Acylcarnitine 3-oxobutanoylcarnitine

    smpdb.ca/view/SMP0123322
    Metabolic

    Once in the matrix, 3-oxobutanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form 3-oxobutanoyl-CoA and L-carnitine. 3 … Acetyl-CoA can go on to enter the TCA cycle, or it can react with L-carnitine to form L-acetylcarnitine in a reaction catalyzed by Carnitine O-acetyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-acetyltransferase, Carnitine O-palmitoyltransferase 2, mitochondrial
  10. Pathway

    Acylcarnitine 3,4,5-trihydroxypentanoylcarnitine

    smpdb.ca/view/SMP0123323
    Metabolic

    This reaction is catalyzed by carnitine O-palmitoyltransferase. This enzyme resides in the mitochondrial outer membrane. … Once in the matrix, 3,4,5-trihydroxypentanoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form 3,4,5-trihydroxypentanoyl-CoA

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-acetyltransferase, Carnitine O-palmitoyltransferase 2, mitochondrial