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E3 ubiquitin-protein ligase HUWE1
go.drugbank.com/bio_entities/BE0016469TargetHumansUbiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). … Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542).
Synonyms: Homologous to E6AP carboxyl terminus homologous protein 9Choline salicylate
go.drugbank.com/drugs/DB14006ApprovedNutraceuticalThe UK government has regulated its use, due to toxicity in those under 16 years of age. … Topical oral salicylate gels are no longer indicated for people younger than 16 years for pain associated with infant teething, orthodontic devices, cold sores, or mouth ulcers [L2134].
Products: DENCOL JEL SPREY, 20 G, Colident %8.71 jel sprey, 20 GIsocarboxazid
go.drugbank.com/drugs/DB01247ApprovedIsocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor. … [T115] It was first introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and first FDA approved as a prescription drug on July 1st, 1959.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeCalcium threonate
go.drugbank.com/drugs/DB11168ApprovedWithdrawnTherapeutic efficacy of calcium threonate in reducing was studied and investigated due to the hypothesis that it may play a role in the mineralization process through its positive action on vitamin C.
Mixtures: Corvite 150, Ferrex 150 Forte PlusTasimelteon
go.drugbank.com/drugs/DB09071ApprovedInvestigationalBy activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism … In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesRose bengal
go.drugbank.com/drugs/DB11182ApprovedInvestigationalThe clinical applications of rose bengal as injectable formulation under the name PV-10 in melanoma, breast cancer and skin conditions such as eczema and psoriasis are being investigated in clinical trials … Its disodium salt in ophthalmic solutions has been used as a diagnostic agent in suspected damage to conjunctival and corneal cells.
Capmatinib
go.drugbank.com/drugs/DB11791ApprovedInvestigational[A199122] Aberrant c-Met activation - via mutations, amplification, and/or overexpression - is known to occur in many types of cancer, and leads to overactivation of multiple downstream signaling pathways … a mutation that leads to mesenchymal-epithelial transition (MET) exon 14 skipping.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsAcquired Aplastic Anaemia
go.drugbank.com/conditions/DBCOND0055951Drugs: OxymetholoneSynonyms: Anaemia: [acquired aplastic] or [normocytic due to aplasia]Acute Hepatic Porphyria (AHP)
go.drugbank.com/conditions/DBCOND0109617Synonyms: Porphyria due to delta-aminolevulinate dehydratase deficiency