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Dengue virus serotype 4
go.drugbank.com/drugs/DB22667ApprovedDengue virus serotype 4 is a serotype of _Orthoflavivirus denguei_ known to cause dengue fever. … [L53368] Qdenga was approved for use in the European Union in December 2022.[L53373]
Synonyms: Dengue virus type 4, Dengue virus serotype 4Tienilic acid
go.drugbank.com/drugs/DB04831ApprovedWithdrawnTienilic acid, or ticrynafen, is a diuretic drug with uric acid-lowering action which was marketed for the treatment of hypertension. … It was withdrawn in 1982 after case reports in the United States suggested a link between ticrynafen and hepatitis. (Manier et al., 1982)
Synonyms: (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid, 4-(2-Theonyl)-2,3-dichlorphenoxyessigsäureCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2C9 InhibitorsPhenylacetic acid
go.drugbank.com/drugs/DB09269ApprovedBecause it is used in the illicit production of phenylacetone (used in the manufacture of substituted amphetamines), it is subject to controls in countries including the United States and China. … Phenylacetic acid is an organic compound containing a phenyl functional group and a carboxylic acid functional group. It is a white solid with a disagreeable odor.
Synonyms: ANTINEOPLASTON AS 2-1 COMPONENT PHENYLACETIC ACID, α-toluic acidLisocabtagene maraleucel
go.drugbank.com/drugs/DB16582ApprovedInvestigational[A228493,L31588] Lisocabtagene maraleucel is a genetically modified autologous T-cell therapy that targets CD19, the B-lymphocyte surface antigen B4. … Lisocabtagene maraleucel is a chimeric antigen receptor (CAR) T-cell therapy, similar to [brexucabtagene autoleucel] and [axicabtagene ciloleucel].
Categories: CD19-Directed Genetically Modified Autologous T-cell ImmunotherapiesDeferoxamine
go.drugbank.com/drugs/DB00746ApprovedInvestigationalIt forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Synonyms: Deferrioxamine BCategories: Compounds used in a research, industrial, or household settingColfosceril palmitate
go.drugbank.com/drugs/DB09114ApprovedWithdrawn[L1109] Nowadays colfosceril palmitate is under the state of canceled post-marketing. … [A31510] It was part of the first generation of commercially available artificial surfactants.[T70] It was developed by Burroughs Wellcome and it was FDA approved on August 6, 1990.
Synonyms: Palmitate de colfosceril, Palmitato de colfosceriloGivinostat
go.drugbank.com/drugs/DB12645ApprovedInvestigational[L50311,L50316] It is the first non-steroidal drug approved to treat patients with all genetic variants of DMD.[L50316] … [L50316,A263446] Givinostat was granted FDA approval in March 2024 for the treatment of patients ≥6 years of age with Duchenne muscular dystrophy (DMD).
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP2B6 InducersOveporexton
go.drugbank.com/drugs/DB21680ApprovedOveporexton is an orally administered orexin receptor 2 (OX2R) agonist used to treat narcolepsy type 1 (NT1). … [L64069] The FDA approved oveporexton on August 5, 2026 for the treatment of narcolepsy type 1 (narcolepsy with cataplexy) in adults.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesIndium In-111 oxyquinoline
go.drugbank.com/drugs/DB09473ApprovedIndium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detected with a gamma ray camera. … Following intravenous administration, the lipid-soluble complex is able to penetrate platelet cell membranes.
Aminophenazone
go.drugbank.com/drugs/DB01424ApprovedWithdrawnThe FDA suspended the use of aminophenazone due to its association with agranulocytosis, a life-threatening side effect.[A254242,L43942] … In biomedical applications, radiolabelled (13C-labeled) aminophenazone has been used in breath tests to measure the cytochrome P-450 metabolic activity in liver function tests.
Synonyms: 4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, 1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazoloneCategories: Non COX-2 selective NSAIDS, Cytochrome P-450 Substrates