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Givinostat
go.drugbank.com/drugs/DB12645ApprovedInvestigational[L50311,L50316] It is the first non-steroidal drug approved to treat patients with all genetic variants of DMD.[L50316] … [L50316,A263446] Givinostat was granted FDA approval in March 2024 for the treatment of patients ≥6 years of age with Duchenne muscular dystrophy (DMD).
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP2B6 InducersIndium In-111 oxyquinoline
go.drugbank.com/drugs/DB09473ApprovedIndium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detected with a gamma ray camera. … Following intravenous administration, the lipid-soluble complex is able to penetrate platelet cell membranes.
Streptococcus pneumoniae type deOAc15B capsular polysaccharide diphtheria CRM197 protein conjugate antigen
go.drugbank.com/drugs/DB19344ApprovedInvestigationalStreptococcus pneumoniae type deOAc15B capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains de-O-acetylated saccharides of the capsular antigens of _Streptococcus … pneumoniae_ serotype 15B individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of _Corynebacterium diphtheriae_ strain C7 (β197).
Pancrelipase amylase
go.drugbank.com/drugs/DB11065ApprovedInvestigational[T177] The pancrelipase amylase is a single polypeptide chain containing two SH groups and four disulfide bridges. … [L2509] The amylases are enzymes that help in the chemical process of digestion by hydrolizing starch into more available saccharide forms.
Mixtures: Creon 8 Cap, Cotazym Ecs 8Synonyms: Amylase A, 1,4-alpha-D-Glucan glucanohydrolaseDicoumarol
go.drugbank.com/drugs/DB00266ApprovedDicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. … In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Categories: 4-Hydroxycoumarins, Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic IndexSynonyms: 3,3'-methylenebis(4-hydroxy-2H-1-benzopyran-2-one), bis(4-hydroxycoumarin-3-yl)methaneMolsidomine
go.drugbank.com/drugs/DB09282ApprovedWithdrawnMolsidomine is an orally active, long-acting vasodilator, which belongs to the class of medications known as syndnones. … Interestingly, it is being studied as being a preventive measure in cerebral infarction [A31932].
Categories: Heterocyclic Compounds, 1-RingProducts: MOLSIDOMIN 2 HEUMANN, MOLSIDOMIN 4 HEUMANNTucatinib
go.drugbank.com/drugs/DB11652ApprovedInvestigationalTucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. … [L12951] Tucatinib is a promising new treatment for patients with metastatic breast cancer who have not responded adequately to other chemotherapy regimens.[L12945]
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsPozelimab
go.drugbank.com/drugs/DB15218ApprovedInvestigational[L47880] The pathophysiology of this disease is mainly attributed to the deficiency of the CD55 protein, which is the main regulator of the complement cascade.[A261105,A261110,A261115]. … [A261120] Pozelimab is a human, monoclonal immunoglobulin G4<sup>P</sup> antibody against the terminal complement protein C5.
Tivozanib
go.drugbank.com/drugs/DB11800ApprovedInvestigationalRenal cell carcinoma (RCC) is responsible for 3% of cancer cases[A231314] and is one of the 10 most common cancers in adults. The average age of diagnosis is between age 65 to 74. … [L32529] Tivozanib, also known as FOTIVDA, is a kinase inhibitor developed to treat adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) after prior failed systemic therapies
Categories: Cytochrome P-450 Substrates, P-glycoprotein substrates