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Clorazepic acid
go.drugbank.com/drugs/DB00628ApprovedIllicit[A957,L44788] Following administration, clorazepate is rapidly converted to nordiazepam (N-desmethyldiazepam), its active metabolite, before entering systemic circulation. … In September 2020, a black box warning describing these risks was included on the product label of benzodiazepines as per FDA regulation.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingSynonyms: 7-chloro-2,3-dihydro-2,2-dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acidCyclosporine
go.drugbank.com/drugs/DB00091ApprovedInvestigationalVet approved[A174049] Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118] … It is isolated from the fungus _Beauveria nivea_.
Synonyms: Cyclosporin A, Cyclosporine ACategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexPulmonary arterial hypertension WHO functional class I
go.drugbank.com/conditions/DBCOND0160108Synonyms: PAH WHO Group I, Pulmonary Arterial Hypertension WHO Group IRelapsed Cutaneous T-cell Lymphoma Stage I
go.drugbank.com/conditions/DBCOND0168685Drugs: Denileukin diftitoxSynonyms: Relapsed Cutaneous T-cell Lymphoma Stage IMacrophage scavenger receptor types I and II
go.drugbank.com/bio_entities/BE0010942TargetHumansMembrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), ther...
Polypeptides: Macrophage scavenger receptor types I and IISynonyms: Macrophage acetylated LDL receptor I and IIFenofibrate
go.drugbank.com/drugs/DB01039ApprovedInvestigationalFenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil].[A185954] Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia. … [L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993.[L8585]
Mixtures: SIMITRI®145/20MG, PRAVAFEN® CAPSULASCategories: Non-statin Hypolipidemic Agents Indicated for Hyperlipidemia, P-glycoprotein inhibitorsFrangula purshiana bark
go.drugbank.com/drugs/DB15478ApprovedMixtures: Herbalax Forte No 70 Tab, Cholasyn IIProducts: Herbalis Cap 80.5mg, Cascara Sagrada Cap 400mgAdalimumab
go.drugbank.com/drugs/DB00051ApprovedInvestigationalAdalimumab-atto was the first adalimumab biosimilar approved by the FDA in 2016.[L44953] Adalimumab-adaz was approved by the FDA on October 31, 2018. … A high-concentration, citrate-free formulation of Cyltezo® (adalimumab-adbm), a biosimilar to Humira®, was approved by the FDA in May 2024 for the treatment of multiple chronic inflammatory diseases.
Categories: Miscellaneous GI DrugsProducts: HUMIRA 40MG ILO I E FER, AMGEVITA 40MG ILO I E FERRefractory Cutaneous T-cell Lymphoma Stage I
go.drugbank.com/conditions/DBCOND0168686Drugs: Denileukin diftitoxSynonyms: Refractory Cutaneous T-cell Lymphoma Stage IDantrolene
go.drugbank.com/drugs/DB01219ApprovedInvestigationalChemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoin