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Methyclothiazide
go.drugbank.com/drugs/DB00232ApprovedWithdrawn(From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
Categories: methyclothiazide and potassium, Genito Urinary System and Sex HormonesProducts: Duretic 5mgThimerosal
go.drugbank.com/drugs/DB11590ApprovedThiomersal (INN), commonly known in the U.S. as thimerosal, is an organomercury compound. This compound is a well-established and widely used antiseptic and antifungal agent. … Developed in 1927, thimerosal has been and is still being used as a preservative in some cosmetics, topical pharmaceuticals, and biological drug products, which includes vaccines.
Categories: Antiseptics and DisinfectantsZosuquidar
go.drugbank.com/drugs/DB06191InvestigationalIts action mechanism consists of the inhibition of P-glycoproteins; other drugs with this mechanism include tariquidar and laniquidar.
Diphenoxylate
go.drugbank.com/drugs/DB01081ApprovedIllicitInvestigationalThis medication is classified as a Schedule V under the Controlled Substances Act by the Food and Drug Administration (FDA) and the DEA in the United States when used in preparations. … Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.
Mixtures: Diphenoxylate Hydrochloride and Atropine Sulfate, Diphenoxylate Hcl and Atropine SulfateCategories: Alimentary Tract and MetabolismIngenol mebutate
go.drugbank.com/drugs/DB05013ApprovedWithdrawnIngenol mebutate was approved by the FDA in January 2012, and it is marketed under the name Picato®. Picato gel is indicated for the topical treatment of actinic keratosis. … including warts and cancer.
Categories: Skin and Mucous Membrane AgentsBuformin
go.drugbank.com/drugs/DB04830ApprovedWithdrawnBuformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. … It was withdrawn from the market in most countries due to a high risk of causing lactic acidosis.
Categories: Alimentary Tract and MetabolismPoliovirus type 2 antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB10796ApprovedInvestigationalThe vaccine contains purified and inactivated poliovirus type 2 that were grown from a continuous line of monkey kidney cells. … caused by poliovirus Type 2.
Mixtures: Infanrix-IPV+Hib Pulver und Suspension zur Herstellung einer InjektionssuspensionCrizanlizumab
go.drugbank.com/drugs/DB15271ApprovedInvestigationalSickle cell disease can lead to excruciating pain, stroke, infection, and various other complications arising from the blockage of blood vessels. … [A187907] Crizanlizumab, or SEG101, is given once every 4 weeks and may improve patient adherence. It was developed by Novartis and was granted FDA approval on November 15, 2019.
Categories: Blood and Blood Forming Organs, Amino Acids, Peptides, and ProteinsMethyl nicotinate
go.drugbank.com/drugs/DB13882ApprovedFor veterinary purposes, methyl nicotinate is used to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and muscle and joint pains [F64]. … Methyl nicotinate is the methyl ester of [DB00627] that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain.
Pralsetinib
go.drugbank.com/drugs/DB15822ApprovedInvestigationalIt is currently marketed under the brand name GAVRETO™ by Blueprint Medicines.[L15986] … [A202055] Pralsetinib (BLU-667) and [selpercatinib] (LOXO-292) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.
Categories: Antineoplastic and Immunomodulating Agents