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Displaying results 3411 - 3420 of 10000 in total
  1. Drug

    Metenkefalin

    go.drugbank.com/drugs/DB12668
    Investigational

    Metenkefalin is an endogenous opioid and beta-endorphin.[A203225] It has been shown to reduce chromosomal abberations in patients with multiple sclerosis. … [A203210] Metenkefalin, along with [tridecactide], are under investigation as an immunomodulatory therapy for moderate to severe COVID-19.[L13874,L13877]

    Categories: mu-Opioid Receptor Agonist
  2. Drug

    Mirfentanil

    go.drugbank.com/drugs/DB09175
    Experimental

    Mirfentanil is a derivative of fentanyl that presents high selectivity for the mu opioid receptor. … At lower doses, it antagonizes the analgesic effects of alfentanil and substitutes for naloxone in morphine-treated monkeys; however, it also reverses naloxone-precipitated withdrawal in pigeons trained

  3. Drug

    GS-441524

    go.drugbank.com/drugs/DB15686
    Investigational

    [L13775] _In vitro_ studies of GS-441524 have determined it has a higher EC<sub>50</sub> than remdesivir against a number of viruses, meaning GS-441524 is less potent. … GS-441524 is an adenosine nucleotide analog antiviral, similar to [remdesivir].[A203057,L13239] This molecule was patented in 2009.

  4. Drug

    Fluoride ion

    go.drugbank.com/drugs/DB11257
    ApprovedInvestigational

    Fluoride ions are found in various minerals but are only present in trace amounts in water. … It also plays an essential physiological role, such as enhancing the resistance profile and strength of the surface tooth enamel.

    Mixtures: ADDAMEL N, ฟลูโอไรด์ใช้เฉพาะที่ ชนิดเจล 60 วินาที เอพีเอฟ (กลิ่นส้ม)
  5. Drug

    Polycarbophil

    go.drugbank.com/drugs/DB09311
    ApprovedWithdrawn

    Less gas and bloating compared to psyllium laxative products, but can cause heartburn, and belly cramps. It is insoluble in water, dilute acids, and dilute alkali.

    Categories: Compounds used in a research, industrial, or household setting
  6. Drug

    Cinchocaine

    go.drugbank.com/drugs/DB00527
    ApprovedVet approved

    (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)

    Mixtures: ULTRAPROCT %0,09+%0,09+%0,5 MERHEM, 10 G, ULTRAPROCT SUPOZITUAR, 10 ADETSynonyms: 2-N-butoxy-N-(2-diethylaminoethyl)cinchoninamide, 2-butoxy-N-(2-(diethylamino)ethyl)cinchoninamide
  7. Drug

    Rucaparib

    go.drugbank.com/drugs/DB12332
    ApprovedInvestigational

    [A249240] The drug was later approved by the European Commission in May 2018.[L42185] It is currently used to treat recurrent ovarian and prostate cancer in adults.[L42155,L42185]. … Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair.

  8. Drug

    AZX-100

    go.drugbank.com/drugs/DB06323
    Investigational

  9. Drug

    Aptazapine

    go.drugbank.com/drugs/DB09305
    Experimental

    Aptazapine (CGS-7525A) was a tetracyclic antidepressant developed in the 1980s. Aptazapine had noradrenergic and specific serotonergic activity. … It antagonised α2 adrenergic receptors approximately 10 times more effectively than mianserin, antagonised 5-HT2 receptors, agonised H1 receptors, and did not affect reuptake of serotonin or norepinephrine

  10. Drug

    Etuvetidigene Autotemcel

    go.drugbank.com/drugs/DB17593
    ApprovedInvestigational

    Etuvetidigene autotemcel is an autologous gene therapy which includes hematopoietic stem cells (HSCs) that have been genetically modified ex vivo. … [A274878] The WAS protein is expressed on non-erythroid hematopoietic cells and regulates the function of actin filaments in the cytoskeleton.[A274878]