Cinchocaine
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Identification
- Summary
Cinchocaine is an anesthetic used for local or regional anesthesia.
- Brand Names
- Nupercainal, Proctol
- Generic Name
- Cinchocaine
- DrugBank Accession Number
- DB00527
- Background
A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
- Type
- Small Molecule
- Groups
- Approved, Vet approved
- Structure
- Weight
- Average: 343.4632
Monoisotopic: 343.225977187 - Chemical Formula
- C20H29N3O2
- Synonyms
- 2-butoxy-N-(2-(diethylamino)ethyl)cinchoninamide
- 2-butoxy-N-(α-diethylaminoethyl)cinchoninamide
- 2-butoxy-N-(β-diethylaminoethyl)cinchoninamide
- 2-butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide
- 2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide
- 2-butoxyquinoline-4-carboxylic acid diethylaminoethylamide
- 2-N-butoxy-N-(2-diethylaminoethyl)cinchoninamide
- Cinchocaine
- Cinchocainum
- Cincocainio
- Dibucaine
- N-(2-(diethylamino)ethyl)-2-butoxycinchoninamide
- α-butyloxycinchonic acid-γ-diethylethylenediamine
- α-butyloxycinchoninic acid diethylethylenediamide
Pharmacology
- Indication
For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination for symptomatic treatment of Hemorrhoids Combination Product in combination with: Framycetin (DB00452), Hydrocortisone (DB00741) •••••••••••• •••••••• Used in combination to treat Hemorrhoids Combination Product in combination with: Framycetin (DB00452), Hydrocortisone (DB00741) •••••••••••• •••••••• Symptomatic treatment of Hemorrhoids ••• ••• Treatment of Itchy skin ••• ••• Symptomatic treatment of Skin irritation ••• ••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Dibucaine is an amide-type local anesthetic, similar to lidocaine.
- Mechanism of action
Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions through sodium channel inhibition. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
Target Actions Organism ASodium channel protein type 5 subunit alpha inhibitorHumans ASodium channel protein type 10 subunit alpha inhibitorHumans UCalmodulin inhibitorHumans - Absorption
In general, ionized forms (salts) of local anesthetics are not readily absorbed through intact skin. However, both nonionized (bases) and ionized forms of local anesthetics are readily absorbed through traumatized or abraded skin into the systemic circulation.
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
Primarily hepatic.
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Subcutaneous LD50 in rat is 27 mg/kg. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.
- Pathways
Pathway Category Dibucaine Action Pathway Drug action - Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when Cinchocaine is combined with 1,2-Benzodiazepine. Abemaciclib The risk or severity of methemoglobinemia can be increased when Abemaciclib is combined with Cinchocaine. Abiraterone The risk or severity of methemoglobinemia can be increased when Abiraterone is combined with Cinchocaine. Acebutolol Cinchocaine may increase the bradycardic activities of Acebutolol. Acetaminophen The risk or severity of methemoglobinemia can be increased when Acetaminophen is combined with Cinchocaine. - Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Cinchocaine hydrochloride Z97702A5DG 61-12-1 IVHBBMHQKZBJEU-UHFFFAOYSA-N - International/Other Brands
- Cincain / Nupercaine / Sovcaine
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image CVS Hemorrhoidal Topical Analgesic Ointment 10 mg/1g Topical CVS Health 2014-01-17 Not applicable US Dibucaine Ointment 1 g/100g Topical E. Fougera & Co. a division of Fougera Pharmaceuticals Inc. 1968-01-01 Not applicable US Dibucaine Ointment 0.01 g/1g Topical NUGERI LLC 2021-05-01 Not applicable US Dibucaine Ointment 0.28 g/28g Topical Akron Pharma Inc. 2021-11-04 Not applicable US Dibucaine Ointment 0.28 g/28g Topical Geritrex Llc 2015-07-31 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image DECATYLEN LOZENGE Cinchocaine hydrochloride (0.03 mg) + Dequalinium chloride (0.25 mg) Lozenge Oral APEX PHARMA MARKETING PTE. LTD. 1990-06-25 Not applicable Singapore DECATYLEN LOZENGES Cinchocaine hydrochloride (0.03 mg) + Dequalinium chloride (0.25 mg) Lozenge Oral MEPHARM (MALAYSIA) SDN. BHD. 2020-09-08 2024-06-28 Malaysia FAKTU Cinchocaine hydrochloride (2.5 mg) + Policresulen (100 mg) Suppository Rectal Pharos Indonesia 2014-06-10 2024-12-20 Indonesia FAKTU Cinchocaine hydrochloride (10 mg/g) + Policresulen (50 mg/g) Ointment Pharos Indonesia 2019-07-15 2026-02-16 Indonesia FAKTU SUPPOSITORY Cinchocaine hydrochloride (2.5 mg) + Policresulen (100 mg) Suppository Rectal TAKEDA PHARMACEUTICALS (ASIA PACIFIC) PTE. LTD. 1988-04-26 Not applicable Singapore - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Dibucaine HCl 0.5% / Lidocaine 15% / Phenylephrine HCl 1% / Prilocaine 5% Cinchocaine hydrochloride (0.5 g/100g) + Lidocaine (15 g/100g) + Phenylephrine hydrochloride (1 g/100g) + Prilocaine (5 g/100g) Ointment Topical Sincerus Florida, LLC 2019-05-11 Not applicable US
Categories
- ATC Codes
- D04AB02 — Cinchocaine
- D04AB — Anesthetics for topical use
- D04A — ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
- D04 — ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
- D — DERMATOLOGICALS
- Drug Categories
- Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
- Amides
- Analgesics and Anesthetics
- Anesthetics
- Anesthetics for Topical Use
- Anesthetics, Local
- Antipruritics and Local Anesthetics
- Antipruritics, Incl. Antihistamines, Anesthetics, Etc.
- Cell-mediated Immunity
- Central Nervous System Agents
- Central Nervous System Depressants
- Cholinesterase Inhibitors
- Dermatologicals
- Heterocyclic Compounds, Fused-Ring
- Increased Histamine Release
- Local Anesthetics (Amide)
- Nervous System
- Ophthalmologicals
- Otologicals
- Peripheral Nervous System Agents
- Quinolines
- Sensory Organs
- Sensory System Agents
- Standardized Chemical Allergen
- Vasoprotectives
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as quinolones and derivatives. These are compounds containing a quinoline moiety which bears a ketone group.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Quinolines and derivatives
- Sub Class
- Quinolones and derivatives
- Direct Parent
- Quinolones and derivatives
- Alternative Parents
- Alkyl aryl ethers / Pyridines and derivatives / Benzenoids / Heteroaromatic compounds / Trialkylamines / Propargyl-type 1,3-dipolar organic compounds / Carboximidic acids / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- Alkyl aryl ether / Amine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Carboximidic acid / Carboximidic acid derivative / Ether / Heteroaromatic compound / Hydrocarbon derivative
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- tertiary amino compound, aromatic ether, monocarboxylic acid amide (CHEBI:247956)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- L6JW2TJG99
- CAS number
- 85-79-0
- InChI Key
- PUFQVTATUTYEAL-UHFFFAOYSA-N
- InChI
- InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24)
- IUPAC Name
- 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
- SMILES
- CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC
References
- Synthesis Reference
- US1825623
- General References
- Abdel-Ghani NT, Youssef AF, Awady MA: Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry. Farmaco. 2005 May;60(5):419-24. [Article]
- Souto-Padron T, Lima AP, Ribeiro Rde O: Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi. Parasitol Res. 2006 Sep;99(4):317-20. Epub 2006 Apr 13. [Article]
- Nounou MM, El-Khordagui LK, Khalafallah N: Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles. Acta Pol Pharm. 2005 Sep-Oct;62(5):369-79. [Article]
- External Links
- Human Metabolome Database
- HMDB0014668
- KEGG Drug
- D00733
- KEGG Compound
- C07879
- PubChem Compound
- 3025
- PubChem Substance
- 46506734
- ChemSpider
- 2917
- BindingDB
- 48532
- 3339
- ChEBI
- 247956
- ChEMBL
- CHEMBL1086
- ZINC
- ZINC000001530939
- Therapeutic Targets Database
- DAP000507
- PharmGKB
- PA449286
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Cinchocaine
- MSDS
- Download (73.8 KB)
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data
Pharmacoeconomics
- Manufacturers
- Novartis pharmaceuticals corp
- Packagers
- Medisca Inc.
- Novartis AG
- Perrigo Co.
- Dosage Forms
Form Route Strength Ointment Topical 10 mg/1g Lozenge Oral 0.25 mg Lozenge Oral Cream Topical 10 mg/1g Ointment Topical 0.01 g/1g Ointment Topical 0.28 g/28g Ointment Topical 1 g/100g Ointment Topical Ointment Suppository Rectal 2.5 mg Ointment Rectal; Topical 1 % Cream Topical Gel Buccal; Dental; Topical Ointment Rectal Ointment Rectal; Topical Kit Cutaneous Suppository Rectal - Prices
Unit description Cost Unit Dibucaine hcl powder 4.74USD g Nupercainal 1% ointment 0.15USD g Dibucaine 1% ointment 0.12USD g DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 99-101 °C (HCl salt) Not Available water solubility 42 mg/L (at 21 °C) BEILSTEIN logP 4.40 HANSCH,C ET AL. (1995) logS -3.7 ADME Research, USCD pKa 8.85 SANGSTER (1994) - Predicted Properties
Property Value Source Water Solubility 0.0389 mg/mL ALOGPS logP 3.79 ALOGPS logP 3.7 Chemaxon logS -4 ALOGPS pKa (Strongest Acidic) 14.57 Chemaxon pKa (Strongest Basic) 9.04 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 54.46 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 102.12 m3·mol-1 Chemaxon Polarizability 40.78 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9968 Blood Brain Barrier + 0.9876 Caco-2 permeable + 0.5187 P-glycoprotein substrate Substrate 0.8702 P-glycoprotein inhibitor I Inhibitor 0.7536 P-glycoprotein inhibitor II Non-inhibitor 0.8862 Renal organic cation transporter Non-inhibitor 0.6349 CYP450 2C9 substrate Non-substrate 0.8297 CYP450 2D6 substrate Non-substrate 0.6415 CYP450 3A4 substrate Substrate 0.6842 CYP450 1A2 substrate Inhibitor 0.9107 CYP450 2C9 inhibitor Non-inhibitor 0.907 CYP450 2D6 inhibitor Inhibitor 0.8932 CYP450 2C19 inhibitor Non-inhibitor 0.9025 CYP450 3A4 inhibitor Non-inhibitor 0.8309 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.6424 Ames test AMES toxic 0.6038 Carcinogenicity Non-carcinogens 0.8128 Biodegradation Not ready biodegradable 1.0 Rat acute toxicity 2.6763 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.8924 hERG inhibition (predictor II) Inhibitor 0.6851
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 192.1912442 predictedDarkChem Lite v0.1.0 [M-H]- 194.4440442 predictedDarkChem Lite v0.1.0 [M-H]- 179.98798 predictedDeepCCS 1.0 (2019) [M+H]+ 192.6148442 predictedDarkChem Lite v0.1.0 [M+H]+ 194.9590442 predictedDarkChem Lite v0.1.0 [M+H]+ 182.34598 predictedDeepCCS 1.0 (2019) [M+Na]+ 192.5290442 predictedDarkChem Lite v0.1.0 [M+Na]+ 194.5266442 predictedDarkChem Lite v0.1.0 [M+Na]+ 188.43912 predictedDeepCCS 1.0 (2019)
Targets
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity)
- Specific Function
- ankyrin binding
- Gene Name
- SCN5A
- Uniprot ID
- Q14524
- Uniprot Name
- Sodium channel protein type 5 subunit alpha
- Molecular Weight
- 226937.475 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Oka M, Itoh Y, Fujita T: Halothane attenuates the cerebroprotective action of several Na+ and Ca2+ channel blockers via reversal of their ion channel blockade. Eur J Pharmacol. 2002 Oct 4;452(2):175-81. [Article]
- Louro SR, Anteneodo C, Wajnberg E: Carboxyl groups at the membrane interface as molecular targets for local anesthetics. Biophys Chem. 1998 Aug 4;74(1):35-43. [Article]
- Ryan SE, Demers CN, Chew JP, Baenziger JE: Structural effects of neutral and anionic lipids on the nicotinic acetylcholine receptor. An infrared difference spectroscopy study. J Biol Chem. 1996 Oct 4;271(40):24590-7. [Article]
- Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms
- Specific Function
- transmembrane transporter binding
- Gene Name
- SCN10A
- Uniprot ID
- Q9Y5Y9
- Uniprot Name
- Sodium channel protein type 10 subunit alpha
- Molecular Weight
- 220623.605 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Louro SR, Anteneodo C, Wajnberg E: Carboxyl groups at the membrane interface as molecular targets for local anesthetics. Biophys Chem. 1998 Aug 4;74(1):35-43. [Article]
- Ryan SE, Demers CN, Chew JP, Baenziger JE: Structural effects of neutral and anionic lipids on the nicotinic acetylcholine receptor. An infrared difference spectroscopy study. J Biol Chem. 1996 Oct 4;271(40):24590-7. [Article]
- Kind
- Protein group
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335)
- Specific Function
- adenylate cyclase activator activity
Components:
Name | UniProt ID |
---|---|
Calmodulin-1 | P0DP23 |
Calmodulin-2 | P0DP24 |
Calmodulin-3 | P0DP25 |
References
- Muto Y, Kudo S, Nozawa Y: Effects of local anesthetics on calmodulin-dependent guanylate cyclase in the plasma membrane of Tetrahymena pyriformis. Biochem Pharmacol. 1983 Dec 1;32(23):3559-63. [Article]
- Volpi M, Sha'afi RI, Epstein PM, Andrenyak DM, Feinstein MB: Local anesthetics, mepacrine, and propranolol are antagonists of calmodulin. Proc Natl Acad Sci U S A. 1981 Feb;78(2):795-9. [Article]
- Liu SH, Fu WM, Lin-Shiau SY: Studies on the inhibition by chlorpromazine of myotonia induced by ion channel modulators in mouse skeletal muscle. Eur J Pharmacol. 1993 Jan 26;231(1):23-30. [Article]
- Sambandam T, Gunasekaran M: Purification and properties of calmodulin from Phymatotrichum omnivorum. Microbios. 1993;73(294):61-74. [Article]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters
- Specific Function
- acetylcholinesterase activity
- Gene Name
- BCHE
- Uniprot ID
- P06276
- Uniprot Name
- Cholinesterase
- Molecular Weight
- 68417.575 Da
References
- Elamin B: Dibucaine inhibition of serum cholinesterase. J Biochem Mol Biol. 2003 Mar 31;36(2):149-53. [Article]
Drug created at June 13, 2005 13:24 / Updated at October 21, 2024 12:51