Fluoride ion

Identification

Generic Name

Fluoride ion

DrugBank Accession Number

DB11257

Background

Having a chemical formula of F−, fluoride ion is the simplest inorganic, monatomic anion of fluorine with basic properties. It is considered a trace element. Fluoride ions are found in various minerals but are only present in trace amounts in water. Its various salt forms and minerals play numerous roles as chemical reagents, industrial chemicals, and commercial products. It also plays an essential physiological role, such as enhancing the resistance profile and strength of the surface tooth enamel.

Type

Small Molecule

Groups

Approved

Structure

Download

MOLSDFPDBSMILESInChI

Similar Structures

Structure for Fluoride ion (DB11257)

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Weight

Average: 18.9984
Monoisotopic: 18.998403205

Chemical Formula

F

Synonyms

Not Available

Pharmacology

Indication

Not Available

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Associated Conditions

• Dental Cavity
• Rickets

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Not Available

Food Interactions

No interactions found.

Products

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Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Topex Neutral pH Fluoride Gel Mint	Gel	9 mg/1g	Dental	Dentsply Llc. Professional Division Trading As "Sultan Healthcare"	1974-01-01	Not applicable
Topex Neutral pH Fluoride Gel Strawberry	Gel	9 mg/1g	Dental	Dentsply Llc. Professional Division Trading As "Sultan Healthcare"	1974-01-01	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
D FLUORETTEN 500	Fluoride ion (0.25 mg/1) + Cholecalciferol (500 IU/1)	Tablet			2006-07-01	Not applicable
D FLUORETTEN 500	Fluoride ion (0.25 mg/1) + Cholecalciferol (500 IU/1)	Tablet			2006-07-01	Not applicable
ZYMAFLUOR D 1000	Fluoride ion (0.25 mg) + Cholecalciferol (1000 IU)	Tablet			2006-07-01	Not applicable
ZYMAFLUOR D 500	Fluoride ion (0.25 mg) + Cholecalciferol (500 IU)	Tablet			2006-07-01	Not applicable
ZYMAFLUOR D 500	Fluoride ion (0.25 mg) + Cholecalciferol (500 IU)	Tablet			2006-07-01	Not applicable
ZYMAFLUOR D 500 C C	Fluoride ion (0.25 mg) + Cholecalciferol (500 IU)	Tablet			2006-07-01	Not applicable
ฟลูโอไรด์ใช้เฉพาะที่ ชนิดเจล 60 วินาที เอพีเอฟ (กลิ่นส้ม)	Fluoride ion (1.23 % w/w) + Sodium fluoride (2.72 %)	Gel		บริษัท แอ๊คเตออน (ประเทศไทย) จำกัด จำกัด	2007-11-27	Not applicable
ฟลูโอไรด์ใช้เฉพาะที่ ชนิดเจล 60 วินาที เอพีเอฟ (กลิ่นองุ่น)	Fluoride ion (1.23 % w/w) + Sodium fluoride (2.72 %)	Gel		บริษัท แอ๊คเตออน (ประเทศไทย) จำกัด จำกัด	2007-11-27	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Multi-Vitamin	Fluoride ion (0.50 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Niacin (13.5 mg/1) + Pyridoxine (1.05 mg/1) + Riboflavin (1.2 mg/1) + Thiamine chloride (1.05 mg/1) + Vitamin A (2500 [iU]/1) + Vitamin D (400 [iU]/1)	Tablet, chewable	Oral	Boca Pharmacal, Inc.	2011-12-28	2015-06-30
Multi-Vitamin	Fluoride ion (1.0 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Niacin (13.5 mg/1) + Pyridoxine (1.05 mg/1) + Riboflavin (1.2 mg/1) + Thiamine chloride (1.05 mg/1) + Vitamin A (2500 [iU]/1) + Vitamin D (400 [iU]/1)	Tablet, chewable	Oral	Boca Pharmacal, Inc.	2011-09-06	2014-12-31
Multi-Vitamin Fluoride and Iron Drops	Fluoride ion (0.25 mg/1mL) + Ascorbic acid (35 mg/1mL) + Cholecalciferol (400 [iU]/1mL) + Iron (10 mg/1mL) + Niacin (8 mg/1mL) + Pyridoxine (0.4 mg/1mL) + Riboflavin (0.6 mg/1mL) + Thiamine chloride (0.5 mg/1mL) + Vitamin A (1500 [iU]/1mL) + alpha-Tocopherol succinate (5 [iU]/1mL)	Solution	Oral	Boca Pharmacal, Inc.	2011-04-20	2015-08-31
Multi-Vitamin Fluoride Drops	Fluoride ion (0.25 mg/1mL) + Ascorbic acid (35 mg/1mL) + Cholecalciferol (400 [iU]/1mL) + Cyanocobalamin (2 ug/1mL) + Niacin (8 mg/1mL) + Pyridoxine (0.4 mg/1mL) + Riboflavin (0.6 mg/1mL) + Thiamine chloride (0.5 mg/1mL) + Vitamin A (1500 [iU]/1mL) + alpha-Tocopherol succinate (5 [iU]/1mL)	Solution	Oral	H.J. Harkins Company	2011-05-04	Not applicable
Multi-Vitamin Fluoride Drops	Fluoride ion (0.5 mg/1mL) + Ascorbic acid (35 mg/1mL) + Cholecalciferol (400 [iU]/1mL) + Cyanocobalamin (2 ug/1mL) + Niacin (8 mg/1mL) + Pyridoxine (0.4 mg/1mL) + Riboflavin (0.6 mg/1mL) + Thiamine chloride (0.5 mg/1mL) + Vitamin A (1500 [iU]/1mL) + alpha-Tocopherol succinate (5 [iU]/1mL)	Solution	Oral	Boca Pharmacal, Inc.	2011-06-06	2015-08-31
Multi-Vitamin Fluoride Drops	Fluoride ion (0.25 mg/1mL) + Ascorbic acid (35 mg/1mL) + Cholecalciferol (400 [iU]/1mL) + Cyanocobalamin (2 ug/1mL) + Niacin (8 mg/1mL) + Pyridoxine (0.4 mg/1mL) + Riboflavin (0.6 mg/1mL) + Thiamine chloride (0.5 mg/1mL) + Vitamin A (1500 [iU]/1mL) + alpha-Tocopherol succinate (5 [iU]/1mL)	Solution	Oral	Boca Pharmacal, Inc.	2011-05-04	2016-03-31
Multi-Vitamin With Fluoride	Fluoride ion (0.25 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Niacin (13.5 mg/1) + Pyridoxine (1.05 mg/1) + Riboflavin (1.2 mg/1) + Thiamine chloride (1.05 mg/1) + Vitamin A (2500 [iU]/1) + Vitamin D (400 [iU]/1)	Tablet, chewable	Oral	Boca Pharmacal, Inc.	2011-12-28	2015-01-31
Multi-Vitamin With Fluoride	Fluoride ion (0.50 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Niacin (13.5 mg/1) + Pyridoxine (1.05 mg/1) + Riboflavin (1.2 mg/1) + Thiamine chloride (1.05 mg/1) + Vitamin A (2500 [iU]/1) + Vitamin D (400 [iU]/1)	Tablet, chewable	Oral	Golden State Medical Supply, Inc.	2010-12-29	2017-01-02
Multi-Vitamin With Fluoride	Fluoride ion (0.25 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Niacin (13.5 mg/1) + Pyridoxine (1.05 mg/1) + Riboflavin (1.2 mg/1) + Thiamine chloride (1.05 mg/1) + Vitamin A (2500 [iU]/1) + Vitamin D (400 [iU]/1)	Tablet, chewable	Oral	Golden State Medical Supply, Inc.	2010-12-17	2017-01-02
Multi-Vitamin With Fluoride	Fluoride ion (1.0 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Niacin (13.5 mg/1) + Pyridoxine (1.05 mg/1) + Riboflavin (1.2 mg/1) + Thiamine chloride (1.05 mg/1) + Vitamin A (2500 [iU]/1) + Vitamin D (400 [iU]/1)	Tablet, chewable	Oral	Golden State Medical Supply, Inc.	2010-12-17	2017-01-02

Categories

Drug Categories

Not Available

Chemical TaxonomyProvided by Classyfire

Description

This compound belongs to the class of inorganic compounds known as homogeneous halogens. These are inorganic non-metallic compounds in which the largest atom is a nobel gas.

Kingdom

Inorganic compounds

Super Class

Homogeneous non-metal compounds

Class

Homogeneous halogens

Sub Class

Not Available

Direct Parent

Homogeneous halogens

Alternative Parents

Not Available

Substituents

Homogeneous halogen

Molecular Framework

Not Available

External Descriptors

halide anion, monoatomic fluorine (CHEBI:17051) / an anion (F-)

Affected organisms

Not Available

Chemical Identifiers

UNII

Q80VPU408O

CAS number

16984-48-8

InChI Key

KRHYYFGTRYWZRS-UHFFFAOYSA-M

InChI

InChI=1S/FH/h1H/p-1

IUPAC Name

fluoride

SMILES

[F-]

References

General References

Not Available

External Links

Human Metabolome Database

HMDB0000662

KEGG Compound

C00742

PubChem Compound

28179

PubChem Substance

347827955

ChemSpider

26214

BindingDB

26978

RxNav

196213

ChEBI

17051

ChEMBL

CHEMBL1362

PDBe Ligand

F

Wikipedia

Fluoride

PDB Entries

1bs3 / 1e6a / 1lh5 / 1nel / 1t5g / 2akz / 2au6 / 2au9 / 2auu / 2dqz …

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Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Injection, solution, concentrate	Intravenous
Tablet
Tablet, chewable	Oral
Solution	Oral
Suspension / drops	Oral
Gel	Dental	9 mg/1g
Gel

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
logP	0.15	Chemaxon
pKa (Strongest Acidic)	3.17	Chemaxon
Physiological Charge	-1	Chemaxon
Hydrogen Acceptor Count	0	Chemaxon
Hydrogen Donor Count	0	Chemaxon
Polar Surface Area	0 Å2	Chemaxon
Rotatable Bond Count	0	Chemaxon
Refractivity	0.87 m3·mol-1	Chemaxon
Polarizability	0.44 Å3	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	Yes	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available

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Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53