This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Fluoride ion
- DrugBank Accession Number
- DB11257
- Background
Having a chemical formula of F−, fluoride ion is the simplest inorganic, monatomic anion of fluorine with basic properties. It is considered a trace element. Fluoride ions are found in various minerals but are only present in trace amounts in water. Its various salt forms and minerals play numerous roles as chemical reagents, industrial chemicals, and commercial products. It also plays an essential physiological role, such as enhancing the resistance profile and strength of the surface tooth enamel.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Fluoride ion (DB11257)
- Weight
- Average: 18.9984
Monoisotopic: 18.998403205 - Chemical Formula
- F
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Prophylaxis of Dental cavity •••••••••••• ••• Used in combination to prevent Hypovitaminosis d Combination Product in combination with: Cholecalciferol (DB00169) •••••••••••• •••••• •••••• - Contraindications & Blackbox Warnings
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Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Topex Neutral pH Fluoride Gel Mint Gel 9 mg/1g Dental Dentsply Llc. Professional Division Trading As "Sultan Healthcare" 1974-01-01 Not applicable US 
Topex Neutral pH Fluoride Gel Strawberry Gel 9 mg/1g Dental Dentsply Llc. Professional Division Trading As "Sultan Healthcare" 1974-01-01 2023-08-18 US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image D FLUORETTEN 500 Fluoride ion (0.25 mg/1) + Cholecalciferol (500 IU/1) Tablet 2006-07-01 Not applicable Germany 
D FLUORETTEN 500 Fluoride ion (0.25 mg/1) + Cholecalciferol (500 IU/1) Tablet 2006-07-01 Not applicable Germany ZYMAFLUOR D 1000 Fluoride ion (0.25 mg) + Cholecalciferol (1000 IU) Tablet 2006-07-01 Not applicable Germany ZYMAFLUOR D 500 Fluoride ion (0.25 mg) + Cholecalciferol (500 IU) Tablet 2006-07-01 Not applicable Germany ZYMAFLUOR D 500 Fluoride ion (0.25 mg) + Cholecalciferol (500 IU) Tablet 2006-07-01 Not applicable Germany - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Multi-Vitamin Fluoride ion (1.0 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Niacin (13.5 mg/1) + Pyridoxine (1.05 mg/1) + Riboflavin (1.2 mg/1) + Thiamine chloride (1.05 mg/1) + Vitamin A (2500 [iU]/1) + Vitamin D (400 [iU]/1) Tablet, chewable Oral Boca Pharmacal, Inc. 2011-09-06 2014-12-31 US Multi-Vitamin Fluoride ion (0.50 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Niacin (13.5 mg/1) + Pyridoxine (1.05 mg/1) + Riboflavin (1.2 mg/1) + Thiamine chloride (1.05 mg/1) + Vitamin A (2500 [iU]/1) + Vitamin D (400 [iU]/1) Tablet, chewable Oral Boca Pharmacal, Inc. 2011-12-28 2015-06-30 US Multi-Vitamin Fluoride and Iron Drops Fluoride ion (0.25 mg/1mL) + Ascorbic acid (35 mg/1mL) + Cholecalciferol (400 [iU]/1mL) + Iron (10 mg/1mL) + Niacin (8 mg/1mL) + Pyridoxine (0.4 mg/1mL) + Riboflavin (0.6 mg/1mL) + Thiamine chloride (0.5 mg/1mL) + Vitamin A (1500 [iU]/1mL) + alpha-Tocopherol succinate (5 [iU]/1mL) Solution Oral Boca Pharmacal, Inc. 2011-04-20 2015-08-31 US Multi-Vitamin Fluoride Drops Fluoride ion (0.25 mg/1mL) + Ascorbic acid (35 mg/1mL) + Cholecalciferol (400 [iU]/1mL) + Cyanocobalamin (2 ug/1mL) + Niacin (8 mg/1mL) + Pyridoxine (0.4 mg/1mL) + Riboflavin (0.6 mg/1mL) + Thiamine chloride (0.5 mg/1mL) + Vitamin A (1500 [iU]/1mL) + alpha-Tocopherol succinate (5 [iU]/1mL) Solution Oral H.J. Harkins Company 2011-05-04 Not applicable US Multi-Vitamin Fluoride Drops Fluoride ion (0.5 mg/1mL) + Ascorbic acid (35 mg/1mL) + Cholecalciferol (400 [iU]/1mL) + Cyanocobalamin (2 ug/1mL) + Niacin (8 mg/1mL) + Pyridoxine (0.4 mg/1mL) + Riboflavin (0.6 mg/1mL) + Thiamine chloride (0.5 mg/1mL) + Vitamin A (1500 [iU]/1mL) + alpha-Tocopherol succinate (5 [iU]/1mL) Solution Oral Boca Pharmacal, Inc. 2011-06-06 2015-08-31 US
Categories
- Drug Categories
- Not Available
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as homogeneous halogens. These are inorganic non-metallic compounds in which the largest atom is a nobel gas.
- Kingdom
- Inorganic compounds
- Super Class
- Homogeneous non-metal compounds
- Class
- Homogeneous halogens
- Sub Class
- Not Available
- Direct Parent
- Homogeneous halogens
- Alternative Parents
- Not Available
- Substituents
- Homogeneous halogen
- Molecular Framework
- Not Available
- External Descriptors
- halide anion, monoatomic fluorine (CHEBI:17051) / an anion (F-)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Q80VPU408O
- CAS number
- 16984-48-8
- InChI Key
- KRHYYFGTRYWZRS-UHFFFAOYSA-M
- InChI
- InChI=1S/FH/h1H/p-1
- IUPAC Name
- fluoride
- SMILES
- [F-]
References
- General References
- Not Available
- External Links
- PDB Entries
- 1bs3 / 1e6a / 1lh5 / 1nel / 1t5g / 2akz / 2au6 / 2au9 / 2auu / 2dqz … show 83 more
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, solution, concentrate Intravenous Tablet Tablet, chewable Oral Solution Oral Suspension / drops Oral Gel Dental 9 mg/1g Gel - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 0.15 Chemaxon pKa (Strongest Acidic) 3.17 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 0.87 m3·mol-1 Chemaxon Polarizability 0.44 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 108.0462 predictedDeepCCS 1.0 (2019) [M-H]- 108.0462 predictedDeepCCS 1.0 (2019) [M+H]+ 109.7789 predictedDeepCCS 1.0 (2019) [M+H]+ 109.7789 predictedDeepCCS 1.0 (2019) [M+Na]+ 116.56366 predictedDeepCCS 1.0 (2019) [M+Na]+ 116.56366 predictedDeepCCS 1.0 (2019)
Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53