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Vutrisiran

[L34490,L42065] Vutrisiran is commercially available as a conjugate of N-acetylgalactosamine (GalNAc), a residue that enables the delivery of siRNA to hepatocytes. … Vutrisiran is a double-stranded small interfering ribonucleic acid (siRNA) that targets wild-type and mutant transthyretin (TTR) messenger RNA (mRNA).

AVR-RD-05

AVR-RD-05 is a gene therapy comprising genetically modified autologous stem cells transduced _ex vivo_ with a lentiviral vector encoding the human iduronate-2-sulfatase (IDS) enzyme. … It is under investigation for the treatment of Hunter Syndrome (Mucopolysaccharidosis Type II, MPSII).

Bevurogant

The usage of the INN stem '-rogant' in the name indicates that Bevurogant is a retinoic acid receptor-related orphan receptor gamma (RORY) antagonist and inverse agonist. … Bevurogant is a small molecule drug.

Izumerogant

The usage of the INN stem '-rogant' in the name indicates that Izumerogant is a retinoic acid receptor-related orphan receptor gamma (RORY) antagonist and inverse agonist. … Izumerogant is a small molecule drug.

Lumefantrine

Lumefantrine is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy.

Cariprazine

Cariprazine gained its first global approval in the US in September 2015 [A3941] and was later approved by Health Canada in April 2022. … [A247100] It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT_1A receptors and as an antagonist at serotonin 5-HT_2A receptors.

Ferric derisomaltose

[A190528] Ferric derisomaltose is a form of iron used in the treatment of iron deficiency. This drug is a complex of iron (III) hydroxide and derisomaltose. … Iron deficiency is an extremely common condition and is the most frequent cause of anemia worldwide.

Procyclidine

A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.

Norgestrienone

Parachlorophenol

P-chlorophenol is a white crystals with a strong phenol odor. Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible.