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Calcium lactate gluconate
go.drugbank.com/drugs/DB13365InvestigationalMixtures: CALCIUM SANDOZ FORTE 300 MG/2940 MG EFERVESAN TABLET, 10 ADET, CALSOURCE 500 MG (EFFERVESCENT TABLETS)Ponesimod
go.drugbank.com/drugs/DB12016ApprovedInvestigational[A232079] Fingolimod's activity at sphingosine 1-phosphate receptor 3 was suspected to be responsible for a portion of it's adverse effects, and so more selective modulators were developed.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesMRK-003
go.drugbank.com/drugs/DB17015ExperimentalMRK-003 is a potent and selective γ-secretase inhibitor developed by Merck. It is the preclinical analog of [MK-0752], a drug in clinical development.[A252682]
Synonyms: (1'R,4R)-2-(2,2,2-trifluoroethyl)-5'-[(E)-3-[4-(trifluoromethyl)piperidin-1-yl]prop-1-enyl]spiro[1,2,5-thiadiazolidine-4,13'-tricyclo[8.2.1.03,8]trideca-3(8),4,6-triene] 1,1-dioxideIstradefylline
go.drugbank.com/drugs/DB11757ApprovedInvestigationalIstradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. … [A184067] Istradefylline is indicated as an adjunct treatment to [levodopa] and [carbidopa] for Parkinson's disease.[L8237] This drug was first approved in Japan on 25 March 2013.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesOrdesekimab
go.drugbank.com/drugs/DB16649InvestigationalOrdesekimab is under investigation in clinical trial NCT02633020 (Study to Evaluate the Efficacy and Safety of AMG 714 in Adult Patients With Type II Refractory Celiac Disease).
Cinchocaine
go.drugbank.com/drugs/DB00527ApprovedVet approvedIt is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
Mixtures: ULTRAPROCT %0,09+%0,09+%0,5 MERHEM, 10 G, ULTRAPROCT SUPOZITUAR, 10 ADETZinc finger and BTB domain-containing protein 7A
go.drugbank.com/bio_entities/BE0012406TargetHumansAlso directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). … Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity).
Synonyms: Factor that binds to inducer of short transcripts protein 1Mestranol
go.drugbank.com/drugs/DB01357ApprovedWithdrawnIt must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives.
Mixtures: Norinyl 1/50 28 Tab, Norinyl 1/50 21 TabCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesTroglitazone
go.drugbank.com/drugs/DB00197ApprovedWithdrawnTroglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone].
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 Substrates