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Tranylcypromine
go.drugbank.com/drugs/DB00752ApprovedInvestigationalIt also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). … A propylamine formed from the cyclization of the side chain of amphetamine.
Dihydroergotamine
go.drugbank.com/drugs/DB00320ApprovedInvestigational[A239569] The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution … [L38469] Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile.
Categories: Ergot Alkaloids and DerivativesMetal cation symporter ZIP8
go.drugbank.com/bio_entities/BE0009901TransporterHumansProtects, for instance, cells from injury and death at the onset of inflammation (PubMed:18390834). … Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient (PubMed:28481222).
Synonyms: Zrt- and Irt-like protein 8Inulin
go.drugbank.com/drugs/DB00638ApprovedInvestigationalNutraceuticalA starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan.
Categories: inulin and other polyfructosans, Tests for Renal Function and Ureteral InjuriesNicoboxil
go.drugbank.com/drugs/DB12911ApprovedWithdrawnSuch combination topical analgesics are only available for purchase and use (for humans) in some parts of Europe and Asia, like Germany and Australia [F11, F16]. … Nicoboxil has been investigated for the treatment of Acute Low Back Pain, where it is typically considered an effective and safe therapeutic option.
Taletrectinib
go.drugbank.com/drugs/DB18711ApprovedInvestigational[A274118] Taletrectinib was approved by the US FDA in June 2025 for use in patients with advanced ROS1-positive NSCLC.[L53308,L53523] … It is targeted against ROS1, including resistant mutant forms, and shows some inhibitor activity against tropomyosin receptor kinases (TRKs) TRKA, TRKB, and TRKC.
Brexucabtagene autoleucel
go.drugbank.com/drugs/DB15699ApprovedInvestigational[L15148] Brexucabtagene autoleucel was granted full approval by the FDA on July 24, 2020 for the treatment of MCL and acute lymphoblastic leukemia (ALL), and is currently available through Kite Pharma … Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as [ibrutinib] and [acalabrutinib], the prognosis for MCL patients remains poor and those that relapse following BTK inhibitor
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic cell and gene therapyAgmatine
go.drugbank.com/drugs/DB08838ExperimentalUp to now (July 2013), the results of this study have not yet been published. … It is formed when arginine is decarboxylated by the enzyme arginine decarboxylase and is found naturally in ragweed pollen, ergot fungi, octopus muscle, herring sperm, sponges, and the mammalian brain.
Latanoprostene bunod
go.drugbank.com/drugs/DB11660ApprovedThe novelty of this agent subsequently lies in the proposed dual mechanism of action that stems from both its prostaglandin F2-alpha analog latanoprost acid metabolite and its ability to donate NO for … In comparison, both latanoprost and latanoprostene bunod contain a latanoprost acid backbone.
Categories: Antiglaucoma Preparations and MioticsOmadacycline
go.drugbank.com/drugs/DB12455ApprovedInvestigationalinfections caused by gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), and by gram-negative, atypical and anaerobic bacteria, including those resistant to currently available … classes of antibiotics and known to cause diseases such as pneumonias, urinary tract infections, skin diseases and blood-borne infections in both the hospital and community settings.