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Displaying results 3451 - 3460 of 9333 in total
  1. Drug

    Levopropoxyphene

    go.drugbank.com/drugs/DB06793
    ApprovedWithdrawn

    Levopropoxyphene is a stereoisomer of propoxyphene in the form of 2S, 3R enantiomer. It was sold as an antitussive, but it was removed from the market in the 70s.

  2. Drug

    Zolasartan

    go.drugbank.com/drugs/DB20140
    Experimental

    The usage of the INN stem '-sartan' in the name indicates that Zolasartan is a angiotensin II receptor antagonist, antihypertensive (non-peptidic).

    Categories: Agents Acting on the Renin-Angiotensin System
  3. Drug

    Protein S human

    go.drugbank.com/drugs/DB13149
    ApprovedInvestigational

    It serves as a negative feedback mechanism in the coagulation cascade.

  4. Drug

    Mevastatin

    go.drugbank.com/drugs/DB06693
    Experimental

    The compound was proposed to bind to the reductase enzyme and was named compactin. … It was the first discovered agent belonging to the class of cholesterol-lowering medications known as statins.

  5. Drug

    Taurocholic acid

    go.drugbank.com/drugs/DB04348
    Approved

    The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. … It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.

  6. Drug

    M0002

    go.drugbank.com/drugs/DB05091
    Investigational

    It will be of major benefit to those patients not responding satisfactorily to diuretics alone. … M0002 is an orally-active selective vasopressin antagonist that inhibits water re-absorption from the kidneys.

  7. Drug

    Protionamide

    go.drugbank.com/drugs/DB12667
    ApprovedInvestigationalWithdrawn

    Prothionamide has been used in trials studying the treatment of MDR-TB and HIV Infections.

  8. Drug

    Medifoxamine

    go.drugbank.com/drugs/DB13219
    Approved

    Medifoxamine was marketed as an atypical antidepressant, with anxiolyitc properties in France, Spain, and Morrocco in the 1990s but was later withdrawn from the market due to it causing cases of hepatotoxicity

  9. Drug

    VidPrevtyn Beta

    go.drugbank.com/drugs/DB16427
    Approved

    [A245829,L49696] In October 2022, VidPrevtyn Beta was approved in the European Union for use as a booster dose in patients who have previously received a COVID-19 vaccine.[L49691] … comprises a recombinant SARS-CoV-2 spike protein (B.1.351 strain) - produced by recombinant DNA technology using a baculovirus expression system in an insect cell line that is derived from Sf9 cells of the

    Synonyms: SARS-CoV-2 prefusion Spike delta TM protein, recombinant (B.1.351 strain)
  10. Drug

    Trypsin

    go.drugbank.com/drugs/DB11237
    ApprovedInvestigationalVet approved

    Trypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form an acyl-enzyme intermediate [A27241]. … Trypsin also contains an oxyanion hole that stabilizes the charge negative charge on the carbonyl oxygen atom formed from the cleavage of peptide bonds.