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Displaying results 3461 - 3470 of 10000 in total
  1. Drug

    Sparsentan

    go.drugbank.com/drugs/DB12548
    ApprovedInvestigational

    [A257325,A257335,L45310] Compared to [irbesartan], sparsentan reduces proteinuria to a greater extent. … >A</sub>R and 0.8 nM for AT<sub>1</sub>R).

    Categories: Angiotensin 2 Receptor Blocker, Dual Endothelin Type A Receptor/Ang II Subtype 1 Receptor Antagonist (DEARA)
  2. Drug

    Nafamostat

    go.drugbank.com/drugs/DB12598
    Investigational

    Nafamostat is a synthetic serine protease inhibitor that is commonly formulated with hydrochloric acid due to its basic properties.

    Synonyms: p-Guanidinobenzoic acid ester with 6-hydroxy-2-naphthamidine
  3. Drug

    Octenidine

    go.drugbank.com/drugs/DB12624
    Investigational

    Octenidine is under investigation in clinical trial NCT02697162 (Antiseptic-coated Intermittent Urinary Catheter).

    Mixtures: Linola sept 1 mg/g + 10 mg/g Wund-Gel, Linola sept 1 mg/g + 20 mg/g Wund-Spray zur Anwendung auf der Haut, LösungCategories: Heterocyclic Compounds, 1-Ring
  4. Drug

    CC-115

    go.drugbank.com/drugs/DB12740
    Investigational

    CC-115 has been used in trials studying the treatment of Prostate Cancer, Neoplasm Metastasis, Ewing's Osteosarcoma, Glioblastoma Multiforme, and Chronic Lymphocytic Leukemia, among others.

    Categories: Heterocyclic Compounds, 1-Ring
  5. Drug

    Lometrexol

    go.drugbank.com/drugs/DB12769
    Investigational

    Lometrexol has been used in trials studying the treatment of Lung Cancer, Drug/Agent Toxicity by Tissue/Organ, and Unspecified Adult Solid Tumor, Protocol Specific.

    Categories: Heterocyclic Compounds, 2-Ring
  6. Drug

    Pegvaliase

    go.drugbank.com/drugs/DB12839
    ApprovedInvestigational

    to 3690 µmol/L [A33286]. … The presence of a PEG moiety in pegvaliase-pqpz allows a reduced immune response and improved pharmacodynamic stability [A33284].

  7. Drug

    Reproterol

    go.drugbank.com/drugs/DB12846
    Investigational

    Reproterol has been used in trials studying the treatment of Asthma, Exercise-Induced.

    Synonyms: 7-(3-((2-(3,5-Dihydroxyphenyl)-2-hydroxyethyl)amino)propyl)theophyllineCategories: Heterocyclic Compounds, 2-Ring, Selective Beta 2-adrenergic Agonists
  8. Drug

    Miravirsen

    go.drugbank.com/drugs/DB12851
    Investigational

    Miravirsen has been investigated for the treatment of Hepatitis C and Hepatitis C, Chronic.

  9. Drug

    Quizartinib

    go.drugbank.com/drugs/DB12874
    ApprovedInvestigational

    [A260641] Additionally, quizartinib also demonstrates inhibitory activity toward FLT3 with internal tandem duplication (ITD), although with a 10-fold lower affinity compared to wild-type FLT3. … maintenance monotherapy resulted in a 22% reduction in the risk of death.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: N-(5-(1,1-Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)urea
  10. Drug

    RO-4987655

    go.drugbank.com/drugs/DB12933
    Investigational

    RO4987655 has been used in trials studying the treatment of Neoplasms.

    Categories: Heterocyclic Compounds, 1-Ring