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Sevoflurane
go.drugbank.com/drugs/DB01236ApprovedInvestigationalVet approved[A249885] Sevoflurane is three times more potent than [desflurane], but has lower potency compared to [halothane] and [isoflurane]. … [L42340] Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996.
Mecasermin rinfabate
go.drugbank.com/drugs/DB14751ApprovedInvestigationalThe binding of IGF-1 to IGFBP-3 is said to extend the half life and reduce the clearance of IGF-1 in patients with growth hormone resistant syndromes and low levels of IGFBP-3 though this may represent … Mecasermin rinfabate manufactured by Insmed Incorporated under the brand name Iplex was approved by the FDA in 2005[L5722].
Categories: Pituitary and Hypothalamic Hormones and Analogues, Sex Hormones and InsulinsTegafur
go.drugbank.com/drugs/DB09256ApprovedInvestigationalWhen converted and bioactivated to 5-FU, the drug mediates an anticancer activity by inhibiting thymidylate synthase (TS) during the pyrimidine pathway involved in DNA synthesis. 5-FU is listed on the … Tegafur (INN, BAN, USAN) is a prodrug of [DB00544] (5-FU), an antineoplastic agent used as the treatment of various cancers such as advanced gastric and colorectal cancers.
International brands: ESUEEW AN TCategories: Fluorouracil and prodrugs, Antineoplastic and Immunomodulating AgentsCalcium threonate
go.drugbank.com/drugs/DB11168ApprovedWithdrawnCalcium threonate is a calcium salt of threnoic acid and a novel drug developed for the treatment of osteoporosis and as a calcium supplement [A27266]. … The most common form is calcium L-threonate, or (2R,3S)-2,3,4-trihydroxy butyric acid calcium [A27266].
Mixtures: Iron Fumarate and Aspartate, Glycinate, Ascorbic Calcium, Vitamin B12, Folic Acid, Calcium Threonate and Succinic Acid, Iron Aspartate Glycinate and Polysaccharide Complex, Ascorbic Calcium, Vitamin B12, Folic Acid, Calcium Threonate and Succinic AcidChikungunya virus Senegal strain 37997 envelope protein E1
go.drugbank.com/drugs/DB21767ApprovedInvestigationalOne of three components of a recombinant Chikungunya virus vaccine called Vimkunya.
MK-8189
go.drugbank.com/drugs/DB19153InvestigationalMK-8189 is under investigation in clinical trial NCT04624243 (Efficacy and Safety of MK-8189 in Participants With an Acute Episode of Schizophrenia (MK-8189-008)).
Pegademase
go.drugbank.com/drugs/DB00061ApprovedWithdrawnBovine adenosine deaminase derived from bovine intestine that has been extensively pegylated for extended serum half life.
Categories: Enzymes and Coenzymes, Antineoplastic and Immunomodulating AgentsrdESAT-6
go.drugbank.com/drugs/DB21906ApprovedrdESAT-6 is a recombinant dimer of _Mycobacterium tuberculosis_ early secretory antigenic target used as an ingredient in the diagnostic agent SIILTIBCY along with [rCFP-10].[L53638]
Lasofoxifene
go.drugbank.com/drugs/DB06202ApprovedInvestigationalWithdrawnIt was initially developed as Oporia by Pfizer as a treatment for postmenopausal osteoporosis and vaginal atrophy, in which were both rejected for approval by FDA. … It is a naphthalene derivative marketed for prevention and treatment of osteoporosis and for the treatment of vaginal atrophy.
Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital SystemDimercaprol
go.drugbank.com/drugs/DB06782ApprovedDimercaprol has toxic potential, and its use may be followed by a variety of adverse effects. … It was developed as an experimental antidote against the arsenic-based poison gas Lewisite. It has been used clinically since 1949 in arsenic, cadmium and mercury poisoning.