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Displaying results 3611 - 3620 of 10000 in total
  1. Target

    Inositol polyphosphate 5-phosphatase OCRL

    go.drugbank.com/bio_entities/BE0013933
    EnzymeHumans

    Also, is able to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:15474001, PubMed:40969890, PubMed:7761412). … Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic

    Polypeptides: Inositol polyphosphate 5-phosphatase OCRLSynonyms: Inositol polyphosphate 5-phosphatase OCRL-1, Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase
  2. Target

    Splicing factor 3B subunit 5

    go.drugbank.com/bio_entities/BE0018936
    TargetHumans

    Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:28781166, PubMed:32494006, PubMed:34822310). The 17S U2...

    Polypeptides: Splicing factor 3B subunit 5Synonyms: Pre-mRNA-splicing factor SF3b 10 kDa subunit
  3. Drug

    Gefitinib

    go.drugbank.com/drugs/DB00317
    ApprovedInvestigational

    Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. … Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa.

    Categories: MATE 1 Inhibitors, Antineoplastic and Immunomodulating AgentsSynonyms: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine, 4-(3'-chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline
  4. Drug

    Levamlodipine

    go.drugbank.com/drugs/DB09237
    ApprovedInvestigational

    [A188940] Levamlodipine was granted FDA approval on 19 December 2019.[L10833] … [L10833] As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine as the active moiety possesses therapeutic activity.

    Mixtures: VOLTRAMOS 5 MG/160 MG FILM KAPLI TABLET, 28 ADET, ALENCAL VALS 5/320 MG TABLETAS RECUBIERTASCategories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substrates
  5. Drug

    Chlorambucil

    go.drugbank.com/drugs/DB00291
    ApprovedInvestigational

    A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. … Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)

    Categories: Antineoplastic and Immunomodulating AgentsSynonyms: N,N-di-2-chloroethyl-γ-p-aminophenylbutyric acid, N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid
  6. Drug

    Phenothrin

    go.drugbank.com/drugs/DB13717
    Investigational

    Categories: Compounds used in a research, industrial, or household setting, Scabicides, Insecticides and RepellentsProducts: ANTI-BIT 408 MG/100 ML ŞAMPUAN, 100 ML, ANTI-BIT 408 MG/100 ML ŞAMPUAN, 150 ML
  7. Drug

    Doripenem

    go.drugbank.com/drugs/DB06211
    ApprovedWithdrawn

    The FDA revised the doripenem label in 2014 to include a warning against use in ventilator-associated pneumonia and to reiterate its safety and efficacy for its approved indications. … In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin), it was found that doripenem carried an increased risk of death and lower clinical cure rates

    Categories: Heterocyclic Compounds, 2-RingProducts: DOREXTRA® DORIPENEM 500 MG, REDIDOR 500 MG /VIAL
  8. Drug

    Fosfomycin

    go.drugbank.com/drugs/DB00828
    ApprovedInvestigational

    [A230348] In terms of chemical structure, fosfomycin is a phosphoenolpyruvate analog and contains a phosphonic group and an epoxide ring. … [A230348] Due to its ease of administration as a single 3-gram oral dose and desirable safety profile, fosfomycin has largely become a first-line therapeutic option for the treatment of uncomplicated

    Synonyms: L-cis-1,2-epoxypropylphosphonic acid, (2R-cis)-(3-Methyloxiranyl)phosphonic acidProducts: Fomicyt 40 mg/ml Pulver zur Herstellung einer Infusionslösung, SOLUFOS® 500 MG
  9. Drug

    Tetrabenazine

    go.drugbank.com/drugs/DB04844
    Approved

    It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. … A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders.

    Categories: Tetrabenazine and isomer, Cytochrome P-450 SubstratesSynonyms: 1,2,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-one, 2-oxo-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine
  10. Drug

    Ifosfamide

    go.drugbank.com/drugs/DB01181
    ApprovedInvestigational

    Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.

    Mixtures: IFEX and MESNEX, IFEX and MESNEXCategories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating Agents