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Palonosetron
go.drugbank.com/drugs/DB00377ApprovedInvestigationalAs of 2008, it is the most recent 5-HT3 antagonist to enter clinical use. … It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy and is the only drug of
Categories: Serotonin 3 Receptor Antagonists, Serotonin 5-HT3 Receptor AntagonistsSynonyms: 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one, (3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-oneEarly Estrogen Receptor Positive Breast Cancer
go.drugbank.com/conditions/DBCOND0173171Drugs: GoserelinSynonyms: Early Estrogen Receptor Positive Breast CancerMetastatic Estrogen Receptor Positive Breast Cancer
go.drugbank.com/conditions/DBCOND0129603Drugs: TamoxifenSynonyms: Metastatic Estrogen Receptor Positive Breast CancerCeritinib
go.drugbank.com/drugs/DB09063ApprovedInvestigationalAbout 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like 4) and ALK (anaplastic lymphoma kinase), which … Following treatment with crizotinib (a first-generation ALK inhibitor), most tumours develop drug resistance due to mutations in key "gatekeeper" residues of the enzyme.
Categories: Receptor Protein-Tyrosine Kinases, antagonists & inhibitors, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: N-{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propane-2-sulfonamideLabetalol
go.drugbank.com/drugs/DB00598ApprovedInvestigationalLabetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. … [L7727,L7730] Labetalol was granted FDA approval on 1 August 1984.[L7724]
Categories: Adrenergic alpha-1 Receptor Antagonists, Cytochrome P-450 SubstratesSynonyms: 5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide, 3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcoholElivaldogene autotemcel
go.drugbank.com/drugs/DB16746ApprovedElivaldogene autotemcel is a gene therapy consisting of genetically modified autologous cells. … _ABCD1_ gene that codes for ALDP.
International brands: Lenti-DCategories: Cellular and Gene TherapyBretylium
go.drugbank.com/drugs/DB01158ApprovedRecent evidence has shown that bretylium may also inhibit the Na,K-ATPase by binding to the extracellular K-site. … The primary mode of action for bretylium is thought to be inhibition of voltage-gated K(+) channels.
Synonyms: 2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium, N-ethyl-N,N-dimethyl-2-bromobenzenemethanaminiumMixtures: Bretylium Tosylate 0.4% and Dextrose 5% Inj, Bretylium Tosylate 0.2% and Dextrose 5% InjAluminum sulfate
go.drugbank.com/drugs/DB11239ApprovedMedically, it is primarily used as a coagulating agent in minor cuts and abrasions as well as deodorant [L2144]. … It is a chemical agent used in water purification, the pH regulation of garden soil, and other commercial or industrial applications.
Mixtures: DOMEBORO® POLVO, DALIDOMEPOLVO SACHET 2.2 GProducts: Gingi-Aid MAX Z-Twist 1, Gingi-Aid MAX Z-Twist 3Ociperlimab
go.drugbank.com/drugs/DB18947InvestigationalOciperlimab is under investigation in clinical trial NCT04866017 (A Study to Compare Ociperlimab Plus Tislelizumab Versus Durvalumab Following Concurrent Chemoradiotherapy (Ccrt) in Patients With Stage
Synonyms: Immunoglobulin g1, anti-(human receptor tigit) (human-mus musculus monoclonal bgb-a1217 .gamma.1-chain), disulfide with human-mus musculus monoclonal bgb-a1217 .kappa.-chain, dimer, Immunoglobulin g1-kappa, anti-(homo sapiens tigit (t-cell immunoreceptor with ig domain and itim, v-set ig member 9, vsig9, v-set and transmembrane member 3, vstm3)), humanized monoclonal antibody (ociperlimabTumour necrosis factor receptor-associated periodic syndrome
go.drugbank.com/conditions/DBCOND0008484Drugs: CanakinumabSynonyms: TNF-receptor Associated Periodic Syndromes (TRAPS), TNF receptor-associated periodic fever syndrome