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Vinorelbine
go.drugbank.com/drugs/DB00361ApprovedInvestigationalIt was found that there was 4.3-fold variation in vinorelbine clearance across the cohort, suggesting a strong influence of genetics on the clearance of this drug [L2002]. … A study was done on the clearance rate of vinorelbine on individuals with various single polymorphonuclear mutations.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsSynonyms: 5'-NoranhydrovinblastineMethotrimeprazine
go.drugbank.com/drugs/DB01403ApprovedIt has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine.
Synonyms: (-)-(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine, (-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazineCategories: Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT2A Receptor AntagonistsInsulin lispro
go.drugbank.com/drugs/DB00046ApprovedInvestigationalMarketed as the brand name product Humalog, insulin lispro begins to exert its effects within 15 minutes of subcutaneous administration, while peak levels occur 30 to 90 minutes after administration. … Due to its duration of action of around 5 hours, Humalog is considered "bolus insulin" as it provides high levels of insulin in a short period of time to mimic the release of endogenous insulin from the
Mixtures: HUMALOG MIX25 KWIKPEN 100 units/ml, HUMALOG MIX25 KWIKPEN 100 units/mlCategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersPiperazine
go.drugbank.com/drugs/DB00592ApprovedVet approvedWithdrawnFirst used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. … Piperazine was first introduced as an anthelmintic in 1953.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesProducts: HELMICIDE 800 MG 150 ML SURUP, ASEPAR 100 MG 100 ML SURUPEsmolol
go.drugbank.com/drugs/DB00187ApprovedInvestigationalWithdrawnThe FDA withdrew its approval for the use of all parenteral dosage form drug products containing esmolol hydrochloride that supply 250 milligrams/milliliter of concentrated esmolol per 10-milliliter ampule … It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesProducts: Brevibloc 100 mg/10 ml - Infusionslösung, Esmolol Amomed 100 mg/10 ml InfusionslösungAnti-inhibitor coagulant complex
go.drugbank.com/drugs/DB13151ApprovedInvestigationalAnti-inhibitor coagulant complex, also known as FEIBA (factor eight inhibitor bypassing activity), contains several proteins involved in the prothrombinase complex.
Products: Feiba 50 E./ml Pulver und Lösungsmittel zur Herstellung einer Infusionslösung, FEIBA 100 E./ml Pulver und Lösungsmittel zur Herstellung einer InfusionslösungAzathioprine
go.drugbank.com/drugs/DB00993ApprovedInvestigational[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214] … [A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.
Synonyms: 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine, 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurineCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesLevocarnitine
go.drugbank.com/drugs/DB00583ApprovedInvestigationalConstituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.
Mixtures: Q 10 Suprabio +L-CarnitineProducts: METACARTİN 100 MG/ML ŞURUP, 100 ML, GNC PP L-Carnitine 500 mgNimodipine
go.drugbank.com/drugs/DB00393ApprovedInvestigationalNimodipine is used to as an adjunct to improve the neurologic outcome following subarachnoid hemorrhage from ruptured intracranial aneurysm.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-methoxyethyl ester 5-isopropyl esterAlprostadil
go.drugbank.com/drugs/DB00770ApprovedInvestigationalAlprostadil is a chemically-identical synthetic form of prostaglandin E1 (PGE1), a potent vasodilator produced endogenously. In 1996, the FDA approved the use of alprostadil, administered either with an intracavernosal injection or an in...
Products: CAVERJECT POWDER FOR INJECTION 10 mcg/ml, MUSE 1000 MCG