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Displaying results 3791 - 3800 of 10000 in total
  1. Drug

    Velmanase alfa

    go.drugbank.com/drugs/DB12374
    ApprovedInvestigational

    Patients with alpha-mannosidosis have a genetic mutation that causes a deficiency in the lysosomal enzyme alpha-mannosidase, which is an enzyme responsible for breaking down complex sugars in the body. … [L45295] Velmanase alfa is currently not approved in Canada.

  2. Drug

    Calusterone

    go.drugbank.com/drugs/DB01564
    ExperimentalIllicit

    A 17-alkylated orally active androgenic steroid. A Schedule IV drug in Canada.

  3. Drug

    Rolapitant

    go.drugbank.com/drugs/DB09291
    ApprovedInvestigational

    Neurokinin-1 is also known as Tachykinin Receptor 1 (TACR1), Neurokinin 1 Receptor (NK1R), and Substance P Receptor (SPR). … Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its ligand Substance P, which is released in the gut following chemotherapy administration

  4. Drug

    Tozasertib

    go.drugbank.com/drugs/DB19675
    Investigational

    Tozasertib is a small molecule drug. The usage of the INN stem '-sertib' in the name indicates that Tozasertib is a serine/threonine kinase inhibitor. … Tozasertib is under investigation in clinical trial NCT02532868 (A VX-680 (an Aurora Kinase Inhibitor) Study in Patients With Advanced Cancer (0457-002)).

  5. Drug

    Conteltinib

    go.drugbank.com/drugs/DB21262
    Investigational

    Conteltinib is a small molecule drug. The usage of the INN stem '-tinib' in the name indicates that Conteltinib is a tyrosine kinase inhibitor. … Conteltinib is under investigation in clinical trial NCT06970132 (Study of SY-5933 Plus CT-707 in Advanced Solid Tumors With KRAS p.G12C Mutation).

  6. Drug

    Osunprotafib

    go.drugbank.com/drugs/DB21547
    Investigational

    Osunprotafib is a small molecule drug. The usage of the INN stem '-protafib' in the name indicates that Osunprotafib is a human protein tyrosine phosphatase (HPTP) inhibitor. … Osunprotafib is under investigation in clinical trial NCT04777994 (Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors).

  7. Drug

    Zelicapavir

    go.drugbank.com/drugs/DB21662
    Investigational

    Zelicapavir is a small molecule drug. The usage of the INN stem '-capavir' in the name indicates that Zelicapavir is a viral capsid and nucleocapsid inhibitor. … Zelicapavir is under investigation in clinical trial NCT06601192 (A Study to Investigate the Effects of Zelicapavir (EDP-938) on QTc Interval in Healthy Adults).

  8. Drug

    Zoracopan

    go.drugbank.com/drugs/DB21702
    Investigational

    Zoracopan is a small molecule drug. The usage of the INN stem '-copan' in the name indicates that Zoracopan is a complement receptor antagonist/complement inhibitor. … Zoracopan is under investigation in clinical trial NCT06173596 (A Study to Evaluate Potential Drug Interactions Between ALXN2080 and Itraconazole, Fluconazole & Carbamazepine in Healthy Adults).

  9. Drug

    Prademagene zamikeracel

    go.drugbank.com/drugs/DB17895
    ApprovedInvestigational

    [L53008] COL7A1 encodes type VII collagen (C7), which is a major component of anchoring fibrils (AF) that are critical for dermal-epidermal cohesion. … Prademagene zamikeracel is a sheet-based gene therapy comprising autologous cells isolated from skin punch biopsies of patients with mutations in the collagen type VII alpha 1 chain (COL7A1) gene.

    Categories: Complex Mixtures
  10. Drug

    Cefotiam

    go.drugbank.com/drugs/DB00229
    Approved

    One of the cephalosporins that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.

    Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use