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Eleclazine
go.drugbank.com/drugs/DB12394InvestigationalEleclazine has been used in trials studying the treatment of LQT2 Syndrome, Long QT Syndrome, Ischemic Heart Disease, Ventricular Arrhythmia, and Long QT Syndrome Type 3, among others.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-oneEvogliptin
go.drugbank.com/drugs/DB12625InvestigationalEvogliptin has been used in trials studying the treatment and screening of Osteoporosis, Renal Impairment, Type 2 Diabetes Mellitus, Diabetes Mellitis Type 2, and Diabetes Mellitus, Type 2.
Categories: Dipeptidyl Peptidase 4, Heterocyclic Compounds, 1-RingSolute carrier family 52, riboflavin transporter, member 2
go.drugbank.com/bio_entities/BE0004841TargetTransporterHumansMay also act as a receptor for 4-hydroxybutyrate (Probable)
Synonyms: PERV-A receptor 1, Porcine endogenous retrovirus A receptor 1Function: 4-hydroxybutyrate receptor activitySage oil
go.drugbank.com/drugs/DB11199ApprovedNutraceutical*Salvia officinalis* is a common sage and a member of the genus *Salvia*, that includes aromatic and perennial plants with flowers. … Essential oil has been traditionally used in medicine for the relief of pain and the treatment of inflammation and infections, as it is reported to exhibit carminative, antispasmodic, antiseptic, and astringent
Mixtures: GLP-1 Balance SynergyProducts: Stork I SynergyMelphalan flufenamide
go.drugbank.com/drugs/DB16627ApprovedWithdrawnIt has since been withdrawn from the market in the wake of the phase 3 OCEAN trial which showed a decrease in overall survival in comparison to standard treatment with [pomalidomide] and [dexamethasone … Melphalan flufenamide, also known as melflufen or J1, is a prodrug of [melphalan].
Ursodeoxycholic acid
go.drugbank.com/drugs/DB01586ApprovedInvestigational[A256272,A256277] UDCA has been used to treat liver disease for decades: its first use in traditional medicine dates back more than a hundred years. … Ursodeoxycholic acid (UDCA), also known as ursodiol, is a naturally-occurring bile acid that constitutes a minor fraction of the human bile acid pool.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 Enzyme InducersProducts: T-RUXICO, Ursodiol CImatinib
go.drugbank.com/drugs/DB00619ApprovedInvestigational[L42220] Imatinib was approved on February 1st ,2001 by the FDA and November 7th, 2001 by the EMA; however, its European approval has been withdrawn in October 2023.[A263036,L49746,L49751] … [A249305] It was deemed a "miracle drug" due to its clinical success, as oncologist Dr.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: α-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-toluidideDapagliflozin
go.drugbank.com/drugs/DB06292ApprovedInvestigationalDapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. … [A6757] Dapagliflozin has been investigated either as monotherapy or as an adjunct treatment with insulin or other oral hypoglycemic agents.
Mixtures: XIGLIF-M, PLEMTUM-MCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesPhosphoglycerate Kinases
go.drugbank.com/bio_entities/BE0009688EnzymeHumansCatalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nuc...
Synonyms: Cell migration-inducing gene 10 proteinSphingolipid delta(4)-desaturase DES1
go.drugbank.com/bio_entities/BE0011584TargetHumansHas sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (PubMed:11937514, PubMed:30620337, PubMed:30620338). Catalyzes the equilibrium isomerization of retinols (By similar...
Synonyms: Cell migration-inducing gene 15 protein