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Suprofen
go.drugbank.com/drugs/DB00870ApprovedWithdrawnAn ibuprofen-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. It is no longer approved for use in the United States.
Categories: Non COX-2 selective NSAIDS, Cytochrome P-450 SubstratesSynonyms: 2-(4-(2-Thenoyl)phenyl)propionsäure, (±)-2-(p-(2-thenoyl)phenyl)propionic acidRP01
go.drugbank.com/drugs/DB05751ExperimentalIt is designed to induce the immune system to produce antibodies that block Immunoglobulin E (IgE), the key mediator of an allergic response. … RP01 is a novel anti-IgE immunotherapy for allergic individuals.
Entecavir
go.drugbank.com/drugs/DB00442ApprovedInvestigationalEntecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS). … Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine
Categories: Hepatitis B virus, Cytochrome P-450 SubstratesProducts: KALVIR® 1 MG, Tecavir 1 (Entecavir Tablets 1 mg)Zongertinib
go.drugbank.com/drugs/DB18762ApprovedInvestigationalZongertinib is a selective, irreversible tyrosine kinase inhibitor that targets human epidermal growth factor receptor 2 (HER2). … [L53873,A274363] On August 8, 2025, the US FDA granted accelerated approval to zongertinib for the treatment of advanced forms of non-small cell lung cancer (NSCLC) with HER2 tyrosine kinase domain
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingQuinine
go.drugbank.com/drugs/DB00468ApprovedInvestigationalQuinine (GLS-1200) was also investigated in clinical trials for its efficacy in preventing SARS-CoV-2 infection (NCT04408183, terminated) and is planned to be evaluated for preventing sinusitis after endoscopic … Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose.
Synonyms: (R)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanol, (R)-(−)-quinineMixtures: IRUDERM 1C326
go.drugbank.com/drugs/DB06017ExperimentalC326 is an investigational compound under investigation in clinical trial NCT00353756 (Phase 1 Study of Safety and Biological Effects of C326, an Inhibitor of IL-6, in Crohn's Disease) for the treatment … The drug is composed of an IL-6–binding trimer and a IgG-binding domain.
Dalbavancin
go.drugbank.com/drugs/DB06219ApprovedInvestigationalDalbavancin is a second-generation lipoglycopeptide antibiotic that was designed to improve on the natural glycopeptides currently available, such as vancomycin and teicoplanin [A4072, A4073]. … and methicillin-resistant strains), S. pyogenes, S. agalactiae, S. dysgalactiae, the S. anginosus group (including S. anginosus, S. intermedius, and S. constellatus), and Enterococcus faecalis (vancomycin
Products: Dalbavancin Accord 500 mg Pulver für ein Konzentrat zur Herstellung einer Infusionslösung, Dalbavancin ratiopharm 500 mg Pulver für ein Konzentrat zur Herstellung einer InfusionslösungDorzagliatin
go.drugbank.com/drugs/DB15123InvestigationalDorzagliatin is under investigation in clinical trial NCT03173391 (Long-term Efficacy and Safety of HMS5552 in T2DM).
Categories: Drugs Used in Diabetes, Heterocyclic Compounds, 1-RingMibefradil
go.drugbank.com/drugs/DB01388ApprovedWithdrawnMibefradil was withdrawn from the market in 1998 because of potentially harmful interactions with other drugs.
Categories: P-glycoprotein inhibitors, P-glycoprotein substrates