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Aminooxyacetic acid
go.drugbank.com/drugs/DB02079ExperimentalA compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem]
Synonyms: aminoxyacetic acid, (aminooxy)acetic acidCategories: Acids, Acyclic, Carboxylic AcidsPhenobarbital
go.drugbank.com/drugs/DB01174ApprovedInvestigationalIt promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. … A barbituric acid derivative that acts as a nonselective central nervous system depressant.
Categories: Excitatory Amino Acid Agents, Excitatory Amino Acid AntagonistsSynonyms: Phenobarbituric Acid, Phenylethylbarbituric AcidGabapentin
go.drugbank.com/drugs/DB00996ApprovedInvestigationalGabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993.
Categories: Amino Acids, Acids, AcyclicSynonyms: 1-(Aminomethyl)cyclohexaneacetic acidbeta-Alanine
go.drugbank.com/drugs/DB03107InvestigationalSince neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. … beta-Alanine is an amino acid formed in vivo by the degradation of [dihydrouracil] and [carnosine].
Synonyms: 3-aminopropanoic acid, 3-aminopropionic acidCategories: Amino Acids, Amino Acids, Peptides, and ProteinsClorazepic Acid Action Pathway
smpdb.ca/view/SMP0126122Drug actionClorazepate is a benzodiazepine with depressant effects on the central nervous system.8 Benzodiazepines are able to enhance the binding of gamma-aminobutyric acid (GABA) to the GABA type A (GABA-A) receptor … Clorazepic acid or clorazepate is a benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Clorazepic acid · Calcium · Magnesium cation +4 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Sodium-coupled neutral amino acid transporters
go.drugbank.com/bio_entities/BE0009976TargetHumansAlso mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity … May function in the transport of amino acids at the blood-brain barrier (PubMed:10930503, PubMed:15774260).
Polypeptides: Sodium-coupled neutral amino acid symporter 1, Sodium-coupled neutral amino acid symporter 2Synonyms: Amino acid transporter A1, Amino acid transporter A2Sodium-coupled neutral amino acid transporter 3
go.drugbank.com/bio_entities/BE0000285TargetTransporterHumansAlso mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity … Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827).
Polypeptides: Sodium-coupled neutral amino acid transporter 3Synonyms: N-system amino acid transporter 1, System N amino acid transporter 1Brexanolone
go.drugbank.com/drugs/DB11859ApprovedInvestigationalAs of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as the brand name product Zulresso - is the first drug to have ever been approved by the US FDA specifically for the treatment of postpar...
Categories: Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator, Neuroactive Steroid Gamma-Aminobutyric Acid (GABA) A Receptor Positive ModulatorsPregabalin
go.drugbank.com/drugs/DB00230ApprovedInvestigationalPregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter.
Categories: Amino Acids, Acids, AcyclicTriazolam Action Pathway
smpdb.ca/view/SMP0126116Drug actionThese receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. … It binds to an allosteric site between the alpha and gamma subunits of the receptor increasing the inhibitory effects of GABA.
Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2