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Metabolism and Physiological Effects of Phenylacetylglycine
smpdb.ca/view/SMP0126858MetabolicPhenylacetic acid may arise from exposure to styrene (plastic) or through the consumption of fruits and vegetables. … The presence of phenylacetylglycine in urine has been confirmed for dogs, rats and mice. However, the presence of this compound in human urine is controversial.
Drugs: GlycineMetabolism and Physiological Effects of Hippuric Acid
smpdb.ca/view/SMP0123209MetabolicIt can reduce blood clotting and, in the kidney, inhibit organic acid secretion. It is associated with phenylketonuria, propionic acidemia, and tyrosinemia I (genetic metabolic disorders). … After ingestion and absorption in the gut, benzoic acid is transported into the hepatic liver cell from blood where it undergoes two metabolic reactions.
Metabolism and Physiological Effects of Phenyl glucuronide
smpdb.ca/view/SMP0123227MetabolicPhenyl glucuronide is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a glucuronidation reaction in liver hepatic cells.
Metabolism and Physiological Effects of Indoxyl glucuronide
smpdb.ca/view/SMP0123239MetabolicIndoxyl glucuronide is an indole compound that is formed through gut microbial metabolism from dietary tryptophan and a glucuronidation reaction in liver hepatic cells.
Metabolism and Physiological Effects of Kynurenic Acid
smpdb.ca/view/SMP0123300MetabolicKynurenic acid is shown to activate aryl hydrocarbon receptors that can lead to renal impairment, and it also disrupts the electron transport chain and oxidative phosphorylation causing muscle atrophy. … After being transported into a hepatocyte from portal circulation tryptophan undergoes a reaction with the enzyme tryptophan-2,3-dioxygenase to initially form kynurenine and then with a kynurenine aminotransferase
Metabolsim and Physiological Effects of 4-Ethylphenylsulfate
smpdb.ca/view/SMP0125541MetabolicIt has also been found to be related to cardiovascular mortality and to cause cell apoptosis. … phenylalanine is consumed through foods such as milk, eggs, cheese, nuts, soybeans, chicken, beef, pork, beans and fish.
Drugs: Pyridoxal phosphate · Phenylalanine · Tyrosine · Iron · Oxogluric acid · Propanoic acid +3 moreMetabolism and Physiological Effects of Imidazolepropionic Acid
smpdb.ca/view/SMP0126521MetabolicHistidine can be obtained from the diet from foods such as meat and dairy and other foods high in protein. ImP is a very strong basic compound (based on its pKa). … ImP is a metabolite of histidine and it is formed from histidine via a urocanate intermediate in gut microbiota by the enzyme urocanate reductase (urdA).
Drugs: HistidineMetabolism and Physiological Effects of N-Acetylphenylalanine
smpdb.ca/view/SMP0126720MetabolicThe human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G). … N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins.
Drugs: PhenylalanineMetabolism and Physiological Effects of Phenol sulphate
smpdb.ca/view/SMP0126844MetabolicIn experimental models of diabetes, phenol sulphate administration has been shown to induce albuminuria and podocyte damage. … Phenol sulphate can be found in most mammals (mice, rats, sheep, dogs, humans) and likely most animals. Phenol sulphate is a uremic toxin.
Metabolism and Physiological Effects of Androsterone sulfate
smpdb.ca/view/SMP0127012MetabolicSubsequently, 3α-androstanediol and 3α-etiocholanediol are converted by 17β-HSD into androsterone and etiocholanolone, which is followed by their conjugation and excretion. … Then, 5α-DHT and 5β-DHT are converted by 3α-HSD into 3α-androstanediol and 3α-etiocholanediol, respectively.
Drugs: Testosterone