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Displaying results 3991 - 4000 of 7603 in total
  1. Drug

    Ligelizumab

    go.drugbank.com/drugs/DB11856
    Investigational

    Initial trials of ligelizumab suggest a greater efficacy over its predecessor for the treatment of CSU.[A242367] … [A242292] Ligelizumab is currently under investigation for the treatment of chronic spontaneous urticaria (CSU), an autoimmune-driven inflammatory condition.

  2. Drug

    CXD101

    go.drugbank.com/drugs/DB16182
    Investigational

    CXD101 is under investigation in clinical trial NCT03873025 (A Study of CXD101 in Combination With Pembrolizumab for Relapsed or Refractory Diffuse Large B-cell Lymphoma).

  3. Drug

    Lomifylline

    go.drugbank.com/drugs/DB18002
    Approved

    Categories: Drugs for Obstructive Airway Diseases
  4. Pathway

    mTOR Signaling pathway

    smpdb.ca/view/SMP0535455
    Signaling

    mTOR is a serine/threonine kinase forming two distinct multiprotein complexes—mTORC1 (composed of mTOR, Raptor, PRAS40, DEPTOR, and mLST8) and mTORC2 (composed of mTOR, Rictor, mSIN1, Protor, DEPTOR, and mLST8)—that integrate environment...

    Drugs: Arginine · L-Glutamine · Leucine · ATP · Magnesium cation · Zinc
    Enzymes: Cytosolic arginine sensor for mTORC1 subunit 1
  5. Drug

    Palopegteriparatide

    go.drugbank.com/drugs/DB18676
    ApprovedInvestigational

    [L51134] Palopegteriparatide was first approved by the EMA on November 17, 2023, for the treatment of hyperparathyroidism.[L51134] On August 8, 2024, palopegteriparatide was also approved by the FDA.

  6. Drug

    Fasinumab

    go.drugbank.com/drugs/DB12157
    Investigational

    [A241190] It has since been recognized for its role in nociceptive signaling transduction and has thus become an attractive target in the treatment of chronic pain conditions. … It is currently under investigation for the treatment osteoarthritic pain[A241045] and has demonstrated significantly greater pain relief and functional improvement as compared to standard therapy (i.e

  7. Drug

    Aspergillus repens

    go.drugbank.com/drugs/DB10449
    Approved

    Aspergillus repens is a fungus which can provoke allergic reactions. Aspergillus repens extract is used in allergenic testing.

    Mixtures: Number Four Mold Mixture
  8. Drug

    GS-441524

    go.drugbank.com/drugs/DB15686
    Investigational

    GS-441524 is an adenosine nucleotide analog antiviral, similar to remdesivir. This molecule was patented in 2009. In vitro studies of GS-441524 have determined it has a higher EC50 than remdesivir against a number of viruses, meaning GS-...

    Categories: Antivirals for Systemic Use, Experimental Unapproved Treatments for COVID-19
  9. Drug

    BZL101

    go.drugbank.com/drugs/DB05051
    Investigational

    BZL101 is an oral drug designed for the treatment of advanced breast cancer with a novel mechanism of action. BZL101 targets diseased cells while leaving normal cells healthy and intact.

  10. Drug

    Lunacalcipol

    go.drugbank.com/drugs/DB05024
    Investigational

    This proprietary new drug is both a potent inhibitor of CYP24 (the enzyme responsible for the breakdown of vitamin D) and a potent activator of vitamin D signaling pathways.