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Pegloticase
go.drugbank.com/drugs/DB09208ApprovedInvestigational[A249980] However, cases of anaphylaxis and infusion reactions have been reported in patients treated with this drug. … [L42425] Pegloticase has a longer terminal elimination half-life thanks to the addition of a polyethylene glycol (PEG) group.
Categories: Compounds used in a research, industrial, or household settingPirbuterol
go.drugbank.com/drugs/DB01291ApprovedWithdrawnThe precise function of these receptors has not been established. … Pirbuterol is a beta-2 adrenergic bronchodilator.
Categories: Adrenergic beta-2 Receptor Agonists, Selective Beta 2-adrenergic AgonistsLorcaserin
go.drugbank.com/drugs/DB04871ApprovedInvestigationalWithdrawnIt has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. … Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity.
Categories: Serotonin 5-HT2 Receptor Agonists, Serotonin 5-HT2C Receptor AgonistsRGX-111
go.drugbank.com/drugs/DB17632InvestigationalRGX-111 is an adeno-associated virus vector AAV9 designed to deliver the α-L-iduronidase (IDUA) gene. … Developed by REGENXBIO Inc., it was investigated for the treatment of mucopolysaccharidosis Type I (MPS I).[L46666]
Synonyms: Adeno-associated virus vector serotype 9 expressing human a-L-iduronidaseIsoquercetin
go.drugbank.com/drugs/DB12665InvestigationalIsoquercetin has been used in trials studying the treatment of Kidney Cancer, Renal cell carcinoma, Advanced Renal Cell Carcinoma, Thromboembolism of Vein in Pancreatic Cancer, and Thromboembolism of Vein
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: Quercetin-3-O-glucoside, Quercetin 3-O-glucopyranosideMetribolone
go.drugbank.com/drugs/DB02998ExperimentalIt binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors. … A synthetic non-aromatizable androgen and anabolic steroid.
Synonyms: 17-beta-Hydroxy-17-methylestra-4,9,11-trien-3-one2'-fluoro-5-ethylarabinosyluracil
go.drugbank.com/drugs/DB13030Investigational2'-fluoro-5-ethylarabinosyluracil (FAU) has been used in trials studying the treatment of Small Intestine Lymphoma, Stage IV Mantle Cell Lymphoma, Waldenström Macroglobulinemia, Splenic Marginal Zone Lymphoma
Synonyms: 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil, 2'-Fluoro-5-ethyl-1-beta-D-arabinofuranosyluracilCategories: Heterocyclic Compounds, 1-RingPardoprunox
go.drugbank.com/drugs/DB12061InvestigationalPardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. … Pardoprunox has been used in trials studying the treatment of Early Stage Parkinson's Disease and Advanced Stage Parkinson's Disease.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingCD44 antigen
go.drugbank.com/bio_entities/BE0001113TargetHumansCell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720 … components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor
Synonyms: Hyaluronate receptor, Extracellular matrix receptor IIIFunction: cargo receptor activitySmall ribosomal subunit protein uS2
go.drugbank.com/bio_entities/BE0002402TargetHumansAlso functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways.
Synonyms: Laminin receptor 1, 67 kDa laminin receptor