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Pirenzepine
go.drugbank.com/drugs/DB00670ApprovedWithdrawnIt also potentiates the effect of other antiulcer agents such as cimetidine and ranitidine. It is generally well tolerated by patients. … An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function
Categories: Alimentary Tract and Metabolism, Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord)Products: Gastrozepin Tab 50mgZiftomenib
go.drugbank.com/drugs/DB17171ApprovedInvestigational[L54601] Ziftomenib works by preventing the protein-protein interaction between menin and KMT2A, a complex essential for maintaining the proliferation and survival of these leukemic cells. … Ziftomenib is a potent and highly selective menin inhibitor.
Anisotropine methylbromide
go.drugbank.com/drugs/DB00517ApprovedIts use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. … Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant
Droxicam
go.drugbank.com/drugs/DB09215ApprovedWithdrawnDroxicam is an oxicam non-steroidal anti-inflammatory drug and a prodrug of [DB00554]. … It is used to reduce pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.
Categories: Antiinflammatory and Antirheumatic Products, Antiinflammatory and Antirheumatic Products, Non-SteroidsNaloxegol
go.drugbank.com/drugs/DB09049ApprovedInvestigationalIt was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. … The advantage of naloxegol over the opioid antagonist naloxone is that its PEGylated structure allows for high selectivity for peripheral opioid receptors and lack of entry into the central nervous system
Categories: Alimentary Tract and MetabolismDifelikefalin
go.drugbank.com/drugs/DB11938ApprovedInvestigational[A237610] These revelations led to the study of KOR agonists as a potential treatment option in patients suffering from pruritic conditions. … [L36420,L36395] Difelikefalin was later approved by the EMA in April 2022 for the same indication.[L41665]
Albiglutide
go.drugbank.com/drugs/DB09043ApprovedInvestigationalWithdrawnIt is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. … Albiglutide was approved on April 15, 2014 by the FDA.
Categories: Alimentary Tract and Metabolism, Hormones, Hormone Substitutes, and Hormone AntagonistsAurora kinase B
go.drugbank.com/bio_entities/BE0003404TargetHumansThe CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly ( … histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity).
Synonyms: Aurora- and IPL1-like midbody-associated protein 1Abaloparatide
go.drugbank.com/drugs/DB05084ApprovedInvestigationalby the European Commission on December 19, 2022. … [L740] It was first approved by the FDA on April 28, 2017,[A256748] for the treatment of osteoporosis in postmenopausal women and is also used to increase bone density in men with osteoporosis.
Categories: Sex Hormones and Insulins, Amino Acids, Peptides, and ProteinsFlorbetaben F-18
go.drugbank.com/drugs/DB09148ApprovedInvestigationalFlorbetaben is a fluorine-18 (18F)-labeled stilbene derivative used for Positron Emission Tomography (PET) imaging of the brain. This radioactive diagnostic drug is used for the non-invasive detection of the density of beta-amyloid plaqu...