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Displaying results 4041 - 4050 of 10000 in total

Target
E3 ubiquitin-protein transferase MAEA
go.drugbank.com/bio_entities/BE0003374
TargetHumans
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both re...
Synonyms: Cell proliferation-inducing gene 5 protein
Drug
Sodium sulfide
go.drugbank.com/drugs/DB11159
Approved
Sodium sulfide is a chemical compound with a chemical formula Na2S. … Along with other sulfides, the anti-inflammatory and tissue-protective effects of sodium sulfide have been investigated in models of inflammation and oxidative stress.
Drug
Pegloticase
go.drugbank.com/drugs/DB09208
ApprovedInvestigational
[A249980] However, cases of anaphylaxis and infusion reactions have been reported in patients treated with this drug. … [L42425] Pegloticase has a longer terminal elimination half-life thanks to the addition of a polyethylene glycol (PEG) group.
Categories: Compounds used in a research, industrial, or household setting
Drug
Pirbuterol
go.drugbank.com/drugs/DB01291
ApprovedWithdrawn
The precise function of these receptors has not been established. … Pirbuterol is a beta-2 adrenergic bronchodilator.
Categories: Adrenergic beta-2 Receptor Agonists, Selective Beta 2-adrenergic Agonists
Drug
Lorcaserin
go.drugbank.com/drugs/DB04871
ApprovedInvestigationalWithdrawn
It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. … Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity.
Categories: Serotonin 5-HT2 Receptor Agonists, Serotonin 5-HT2C Receptor Agonists
Drug
RGX-111
go.drugbank.com/drugs/DB17632
Investigational
RGX-111 is an adeno-associated virus vector AAV9 designed to deliver the α-L-iduronidase (IDUA) gene. … Developed by REGENXBIO Inc., it was investigated for the treatment of mucopolysaccharidosis Type I (MPS I).[L46666]
Synonyms: Adeno-associated virus vector serotype 9 expressing human a-L-iduronidase
Drug
Isoquercetin
go.drugbank.com/drugs/DB12665
Investigational
Isoquercetin has been used in trials studying the treatment of Kidney Cancer, Renal cell carcinoma, Advanced Renal Cell Carcinoma, Thromboembolism of Vein in Pancreatic Cancer, and Thromboembolism of Vein
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: Quercetin-3-O-glucoside, Quercetin 3-O-glucopyranoside
Drug
Metribolone
go.drugbank.com/drugs/DB02998
Experimental
It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors. … A synthetic non-aromatizable androgen and anabolic steroid.
Synonyms: 17-beta-Hydroxy-17-methylestra-4,9,11-trien-3-one
Drug
2'-fluoro-5-ethylarabinosyluracil
go.drugbank.com/drugs/DB13030
Investigational
2'-fluoro-5-ethylarabinosyluracil (FAU) has been used in trials studying the treatment of Small Intestine Lymphoma, Stage IV Mantle Cell Lymphoma, Waldenström Macroglobulinemia, Splenic Marginal Zone Lymphoma
Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil, 2'-Fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil
Drug
Pardoprunox
go.drugbank.com/drugs/DB12061
Investigational
Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. … Pardoprunox has been used in trials studying the treatment of Early Stage Parkinson's Disease and Advanced Stage Parkinson's Disease.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring