Sodium sulfide
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Name
- Sodium sulfide
- Accession Number
- DB11159
- Description
Sodium sulfide is a chemical compound with a chemical formula Na2S. Sodium sulfide is used in the pulp and paper industry, water treatment, textile industry, and various chemical manufacturing processes including the production of rubber chemicals, sulfur dyes and oil recovery. Along with its hydrate form, sodium sulfide releases hydrogen sulfide (H2S) when in contact with moist air. H2S is an endogenous gaseous transmitter that exhibits anti-inflammatory and antiapoptotic properties. Along with other sulfides, the anti-inflammatory and tissue-protective effects of sodium sulfide have been investigated in models of inflammation and oxidative stress. Interestingly, sodium sulfide was shown to have some cardioprotective role against cardiac ischemia or reperfusion injury, as well as protect lungs against ventilator-induced lung injury 1. However the clinical significance and mechanism of action of sodium sulfide and replication of results across other studies are not yet fully determined.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Sodium sulfide (DB11159)
- Weight
- Average: 78.04
Monoisotopic: 77.95160973 - Chemical Formula
- Na2S
- Synonyms
- Not Available
Pharmacology
Accelerate your drug discovery research with the industry’s only fully connected ADMET dataset, ideal for:Accelerate your drug discovery research with our fully connected ADMET dataset- Indication
- Not Available
- Contraindications & Blackbox Warnings
Contraindications & Blackbox WarningsWith our commercial data, access important information on dangerous risks, contraindications, and adverse effects.Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects- Pharmacodynamics
- Not Available
- Mechanism of action
- Not Available
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
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- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Comprehensive & structured drug product infoFrom application numbers to product codes, connect different identifiers through our commercial datasets.Easily connect various identifiers back to our datasets- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Dr. Scholls Ingrown Toenail Pain Reliever Gel 10 mg/1g Topical Bayer Healthcare Llc. 2003-05-07 2021-02-28 US 
Scholls Wellness Company LLC Ingrown Toenail Gel 1 g/10g Topical Scholls Wellness Company LLC 2021-01-01 Not applicable US Sodium Sufide Gel 0.085 g/8.5g Topical CVS Health 2017-05-22 2017-10-02 US Sodium Sufide Gel 0.085 g/8.5g Topical Walgreens 2018-03-01 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as alkali metal sulfides. These are inorganic compounds containing a sulfur atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is an alkali metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Alkali metal organides
- Sub Class
- Alkali metal sulfides
- Direct Parent
- Alkali metal sulfides
- Alternative Parents
- Inorganic sulfides / Inorganic sodium salts
- Substituents
- Alkali metal sulfide / Inorganic salt / Inorganic sodium salt / Inorganic sulfide
- Molecular Framework
- Not Available
- External Descriptors
- inorganic sodium salt, sulfide salt (CHEBI:76208)
Chemical Identifiers
- UNII
- YGR27ZW0Y7
- CAS number
- 1313-82-2
- InChI Key
- GRVFOGOEDUUMBP-UHFFFAOYSA-N
- InChI
- InChI=1S/2Na.S/q2*+1;-2
- IUPAC Name
- disodium sulfanediide
- SMILES
- [Na+].[Na+].[S--]
References
- General References
- Francis RC, Vaporidi K, Bloch KD, Ichinose F, Zapol WM: Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury. Anesthesiology. 2011 Nov;115(5):1012-21. doi: 10.1097/ALN.0b013e31823306cf. [PubMed:21912243]
- External Links
- PubChem Compound
- 14804
- PubChem Substance
- 347827927
- ChemSpider
- 14120
- 1293719
- ChEBI
- 76208
- ChEMBL
- CHEMBL2107611
- Wikipedia
- Sodium_sulfide
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Withdrawn Treatment ST-Segment Elevation Myocardial Infraction 1 1 Terminated Treatment Impaired kidney function 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gel Topical 10 mg/1g Gel Topical 1 g/10g Gel Topical 0.085 g/8.5g - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP -0.77 ChemAxon pKa (Strongest Acidic) 3.09 ChemAxon Physiological Charge 1 ChemAxon Hydrogen Acceptor Count 0 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 0 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 0 m3·mol-1 ChemAxon Polarizability 1.78 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created on December 03, 2015 16:51 / Updated on June 12, 2020 16:53