This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Sodium sulfide
- DrugBank Accession Number
- DB11159
- Background
Sodium sulfide is a chemical compound with a chemical formula Na2S. Sodium sulfide is used in the pulp and paper industry, water treatment, textile industry, and various chemical manufacturing processes including the production of rubber chemicals, sulfur dyes and oil recovery. Along with its hydrate form, sodium sulfide releases hydrogen sulfide (H2S) when in contact with moist air. H2S is an endogenous gaseous transmitter that exhibits anti-inflammatory and antiapoptotic properties. Along with other sulfides, the anti-inflammatory and tissue-protective effects of sodium sulfide have been investigated in models of inflammation and oxidative stress. Interestingly, sodium sulfide was shown to have some cardioprotective role against cardiac ischemia or reperfusion injury, as well as protect lungs against ventilator-induced lung injury 1. However the clinical significance and mechanism of action of sodium sulfide and replication of results across other studies are not yet fully determined.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Sodium sulfide (DB11159)
- Weight
- Average: 78.04
Monoisotopic: 77.95160973 - Chemical Formula
- Na2S
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Dr. Scholls Ingrown Toenail Pain Reliever Gel 10 mg/1g Topical Bayer Healthcare Llc. 2003-05-07 2021-02-28 US 
Scholls Wellness Company LLC Ingrown Toenail Gel 1 g/10g Topical Scapa Tapes North America, LLC 2021-01-01 Not applicable US Scholls Wellness Company LLC Ingrown Toenail Gel 1 g/10g Topical Scholls Wellness Company LLC 2021-01-01 Not applicable US Sodium Sufide Gel 0.085 g/8.5g Topical Walgreens 2018-03-01 Not applicable US Sodium Sufide Gel 0.085 g/8.5g Topical CVS Health 2017-05-22 2017-10-02 US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as alkali metal sulfides. These are inorganic compounds containing a sulfur atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is an alkali metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Alkali metal organides
- Sub Class
- Alkali metal sulfides
- Direct Parent
- Alkali metal sulfides
- Alternative Parents
- Inorganic sulfides / Inorganic sodium salts
- Substituents
- Alkali metal sulfide / Inorganic salt / Inorganic sodium salt / Inorganic sulfide
- Molecular Framework
- Not Available
- External Descriptors
- inorganic sodium salt, sulfide salt (CHEBI:76208)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- YGR27ZW0Y7
- CAS number
- 1313-82-2
- InChI Key
- GRVFOGOEDUUMBP-UHFFFAOYSA-N
- InChI
- InChI=1S/2Na.S/q2*+1;-2
- IUPAC Name
- disodium sulfanediide
- SMILES
- [Na+].[Na+].[S--]
References
- General References
- Francis RC, Vaporidi K, Bloch KD, Ichinose F, Zapol WM: Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury. Anesthesiology. 2011 Nov;115(5):1012-21. doi: 10.1097/ALN.0b013e31823306cf. [Article]
- External Links
- PubChem Compound
- 14804
- PubChem Substance
- 347827927
- ChemSpider
- 14120
- 1293719
- ChEBI
- 76208
- ChEMBL
- CHEMBL2107611
- Wikipedia
- Sodium_sulfide
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Withdrawn Treatment ST Segment Elevation Myocardial Infarction (STEMI) 1 1 Terminated Treatment Impaired Renal Function 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gel Topical 10 mg/1g Gel Topical 1 g/10g Gel Topical 0.085 g/8.5g - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP -0.77 Chemaxon pKa (Strongest Acidic) 3.09 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 0 m3·mol-1 Chemaxon Polarizability 1.78 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53