Sodium sulfide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Sodium sulfide
Accession Number
DB11159
Description

Sodium sulfide is a chemical compound with a chemical formula Na2S. Sodium sulfide is used in the pulp and paper industry, water treatment, textile industry, and various chemical manufacturing processes including the production of rubber chemicals, sulfur dyes and oil recovery. Along with its hydrate form, sodium sulfide releases hydrogen sulfide (H2S) when in contact with moist air. H2S is an endogenous gaseous transmitter that exhibits anti-inflammatory and antiapoptotic properties. Along with other sulfides, the anti-inflammatory and tissue-protective effects of sodium sulfide have been investigated in models of inflammation and oxidative stress. Interestingly, sodium sulfide was shown to have some cardioprotective role against cardiac ischemia or reperfusion injury, as well as protect lungs against ventilator-induced lung injury 1. However the clinical significance and mechanism of action of sodium sulfide and replication of results across other studies are not yet fully determined.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 78.04
Monoisotopic: 77.95160973
Chemical Formula
Na2S
Synonyms
Not Available

Pharmacology

Pharmacology
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Indication
Not Available
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Medicalerrors
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products
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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Dr. Scholls Ingrown Toenail Pain RelieverGel10 mg/1gTopicalBayer Healthcare Llc.2003-05-072021-02-28US flag
Scholls Wellness Company LLC Ingrown ToenailGel1 g/10gTopicalScholls Wellness Company LLC2021-01-01Not applicableUS flag
Sodium SufideGel0.085 g/8.5gTopicalCVS Health2017-05-222017-10-02US flag
Sodium SufideGel0.085 g/8.5gTopicalWalgreens2018-03-01Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as alkali metal sulfides. These are inorganic compounds containing a sulfur atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal organides
Sub Class
Alkali metal sulfides
Direct Parent
Alkali metal sulfides
Alternative Parents
Inorganic sulfides / Inorganic sodium salts
Substituents
Alkali metal sulfide / Inorganic salt / Inorganic sodium salt / Inorganic sulfide
Molecular Framework
Not Available
External Descriptors
inorganic sodium salt, sulfide salt (CHEBI:76208)

Chemical Identifiers

UNII
YGR27ZW0Y7
CAS number
1313-82-2
InChI Key
GRVFOGOEDUUMBP-UHFFFAOYSA-N
InChI
InChI=1S/2Na.S/q2*+1;-2
IUPAC Name
disodium sulfanediide
SMILES
[Na+].[Na+].[S--]

References

General References
  1. Francis RC, Vaporidi K, Bloch KD, Ichinose F, Zapol WM: Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury. Anesthesiology. 2011 Nov;115(5):1012-21. doi: 10.1097/ALN.0b013e31823306cf. [PubMed:21912243]
PubChem Compound
14804
PubChem Substance
347827927
ChemSpider
14120
RxNav
1293719
ChEBI
76208
ChEMBL
CHEMBL2107611
Wikipedia
Sodium_sulfide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2WithdrawnTreatmentST-Segment Elevation Myocardial Infraction1
1TerminatedTreatmentImpaired kidney function1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
GelTopical10 mg/1g
GelTopical1 g/10g
GelTopical0.085 g/8.5g
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.77ChemAxon
pKa (Strongest Acidic)3.09ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on December 03, 2015 16:51 / Updated on June 12, 2020 16:53