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Cocarboxylase
go.drugbank.com/drugs/DB01987ApprovedInvestigationalThe coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.
Categories: Enzymes and CoenzymesDermatophagoides pteronyssinus
go.drugbank.com/drugs/DB10401ApprovedInvestigationalDermatophagoides pteronyssinus extracts are sterile solutions used for intradermal testing or subcutaneous immunotherapy. This combination is approved for as a year-round, once-a-day tablet that's dissolved under the tongue as a treatmen...
Mixtures: Standardized Mite Mix Dermatophagoides farinae and Dermatophagoides pteronyssinus, Standardized Mite Mix Dermatophagoides farinae and Dermatophagoides pteronyssinusTremelimumab
go.drugbank.com/drugs/DB11771ApprovedInvestigational[A253717] By binding to CTLA-4, tremelimumab enhances T cell-mediated killing of tumours and reduces tumour growth. … [A253717, L43652] Because CTLA-4 is an immune checkpoint that plays a vital role in regulating T cell-mediated immune response, tremelimumab is considered an immune checkpoint inhibitor, which is an emerging
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsAxatilimab
go.drugbank.com/drugs/DB16388ApprovedInvestigational[A264309] Approved treatment options in steroid-refractory cGHVD are limited, and include [ruxolitinib], [ibrutinib], and [belumosudil]. … [L51194] The mainstay of cGVHD treatment are systemic corticosteroids, but they are ineffective in 30-50% of cases.
Categories: Amino Acids, Peptides, and ProteinsDL-Methylephedrine
go.drugbank.com/drugs/DB11278ApprovedMethylephedrine is not legally available in the United States, but has been identified in cases of drug abuse [L2836]. … Methylephedrine is a sympathomimetic amine that appears in various over-the-counter cough and cold medications throughout the world [L2838], [L2839], [L2840].
Synonyms: N-methylephedrine DL-formNorgestrel
go.drugbank.com/drugs/DB09389ApprovedNorgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active.
Categories: norgestrel and estrogen, norgestrel and estrogenStem-cell derived exosome vesicle products
go.drugbank.com/drugs/DB15743ExperimentalOnce secreted into extracellular fluid, exosomes are taken up by their target cells or carried to distant target sites. … These products originate from multiple cellular types, including immunocytes, tumor cells, and mesenchymal stem cells (MSCs) originating from various tissues.
Rucaparib
go.drugbank.com/drugs/DB12332ApprovedInvestigationalBy targeting the genetically-mutated cancer cells that lack a DNA repair mechanism, rucaparib causes cancer cell death and reduces tumour growth. … [A249240] The drug was later approved by the European Commission in May 2018.[L42185] It is currently used to treat recurrent ovarian and prostate cancer in adults.[L42155,L42185].
Categories: Antineoplastic and Immunomodulating AgentsPrezatide
go.drugbank.com/drugs/DB11296ApprovedIt is known to aid wound healing and its potential applications in chronic obstructive pulmonary disease and metastatic colon cancer are currently being investigated. … Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions [A19503]. Prezatide is used in cosmetic products for the skin and hair.
Categories: Amino Acids, Peptides, and ProteinsAlglucosidase alfa
go.drugbank.com/drugs/DB01272ApprovedInvestigationalAlglucosidase alfa degrades glycogen by catalyzing the hydrolysis of a-1,4- and a-1,6- glycosidic linkages of lysosomal glycogen. … It is used for the treatment of Pompe disease (GAA deficiency) in infants and pediatric patients.
Categories: Enzymes and Coenzymes, Alimentary Tract and MetabolismProducts: (Alglucosidase alfa) 50mg Powder for Solution for Infusion