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Displaying results 401 - 410 of 2828 in total
  1. Indication

    Refractory Complex partial seizures

    go.drugbank.com/conditions/DBCOND0022730
    Drugs: Vigabatrin
    Synonyms: SE - status epilepticus, Complex partial status epilepticus
  2. Target

    Broad substrate specificity ATP-binding cassette transporter ABCG2

    go.drugbank.com/bio_entities/BE0001067
    TargetTransporterCarrierHumans

    Among androgen glucuronates, appears to selectively transport dihydrotestosterone-17-glucuronate while displaying no transporter activity toward testosterone, androsterone and etiocholanolone glucuronates … Can transport estrogen and androgen substrates conjugated with glucuronate or sulfate at C-3, C-16 and C-17 positions.

    Polypeptides: Broad substrate specificity ATP-binding cassette transporter ABCG2Synonyms: Placenta-specific ATP-binding cassette transporter
  3. Target

    Solute carrier organic anion transporter family member 1B3

    go.drugbank.com/bio_entities/BE0003659
    TransporterTargetEnzymeHumans

    May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). … Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition (PubMed:26383540).

    Polypeptides: Solute carrier organic anion transporter family member 1B3Synonyms: Organic anion transporter 8, Liver-specific organic anion transporter 2
  4. Target

    Solute carrier family 52, riboflavin transporter, member 2

    go.drugbank.com/bio_entities/BE0004841
    TargetTransporterHumans

    Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino

    Polypeptides: Solute carrier family 52, riboflavin transporter, member 2Synonyms: Riboflavin transporter 3
  5. Target

    Solute carrier family 52, riboflavin transporter, member 3

    go.drugbank.com/bio_entities/BE0019983
    TransporterHumans

    Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino

    Polypeptides: Solute carrier family 52, riboflavin transporter, member 3Synonyms: Riboflavin transporter 2
  6. Drug

    Atidarsagene autotemcel

    go.drugbank.com/drugs/DB17538
    ApprovedInvestigational

    Atidarsagene autotemcel, sold under the brand name Libmeldy, is a gene therapy comprising genetically modified autologous CD34+ enriched hematopoietic stem and progenitor cells transduced _ex vivo_ using

    Categories: Autologous Hematopoietic Stem Cell-Based Gene Therapy, Complex MixturesSynonyms: Autologous CD34+ cell enriched population that contains haematopoietic stem and progenitor cells (HSPC) transduced ex vivo using a lentiviral vector encoding the human arylsulfatase A (ARSA) gene
  7. Target

    Sodium-coupled neutral amino acid transporters

    go.drugbank.com/bio_entities/BE0009976
    TargetHumans

    Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity … The transport activity is specific for L-glutamine, L-histidine and L-asparagine (PubMed:10823827).

    Polypeptides: Sodium-coupled neutral amino acid transporter 3, Sodium-coupled neutral amino acid transporter 4Synonyms: Amino acid transporter A1, System A transporter 1
  8. Drug

    Lumacaftor

    go.drugbank.com/drugs/DB09280
    ApprovedInvestigational

    Mutations in the CFTR gene result in altered production, misfolding, or function of the CFTR protein and consequently abnormal fluid and ion transport across cell membranes. … Consequently, lumacaftor increases successful production of CFTR ion channels and the total number of receptors available for use at the cell membrane for fluid and ion transport.

  9. Drug

    Leucovorin

    go.drugbank.com/drugs/DB00650
    ApprovedInvestigational

    Leucovorin, also known as folinic acid or citrovorum factor, is a reduced form of folic acid that serves as a vital coenzyme in nucleic acid synthesis. Unlike folic acid, leucovorin does not require the enzyme dihydrofolate reductase (DH...

    Mixtures: FERRITIN COMPLEXCategories: Vitamin B Complex
  10. Drug

    ST-003

    go.drugbank.com/drugs/DB18197
    Experimental

    ST-003 is a novel galanin receptor inhibitor being investigated for the treatment of primary sclerosing cholangitis.

    Synonyms: Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu- Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2