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Displaying results 4091 - 4100 of 10000 in total
  1. Target

    Mucin-4

    go.drugbank.com/bio_entities/BE0018599
    TargetHumans

    Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces (PubMed:10880978). These glycoproteins play important roles in ...

    Polypeptides: Mucin-4Synonyms: MUC-4
  2. Drug

    Tetrabenazine

    go.drugbank.com/drugs/DB04844
    Approved

    A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. … It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.

    Synonyms: 1,2,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-one, 2-oxo-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizineCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-Ring
  3. Drug

    Tiaprofenic acid

    go.drugbank.com/drugs/DB01600
    Approved

    Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain.

    Synonyms: 2-(5-Benzyl-2-thienyl)propionsäure, 2-(5-Benzoyl-thiophen-2-yl)-propionic acidCategories: Non COX-2 selective NSAIDS
  4. Target

    Ribonuclease 4

    go.drugbank.com/bio_entities/BE0001924
    TargetHumans

    Cleaves preferentially after uridine bases (PubMed:3467790). Has antimicrobial activity against uropathogenic E.coli (UPEC) (PubMed:33818125). Probably contributes to urinary tract sterility (PubMed:33818125)

    Polypeptides: Ribonuclease 4Synonyms: RNase 4
  5. Target

    Interleukin-4

    go.drugbank.com/bio_entities/BE0003520
    TargetHumans

    Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6 (PubMed:7721895)

    Polypeptides: Interleukin-4Synonyms: IL-4
  6. Target

    Caspase-4

    go.drugbank.com/bio_entities/BE0009964
    TargetHumans

    Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis (PubMed:25119034, PubMed:26375003, PubMed:32109412, PubMed:34671164, PubMed:37001519, PubMed:379937...

    Polypeptides: Caspase-4Synonyms: CASP-4
  7. Target

    Myosin-4

    go.drugbank.com/bio_entities/BE0021470
    TargetHumans

    Muscle contraction

    Polypeptides: Myosin-4Synonyms: Myosin heavy chain 4
  8. Drug

    Interferon alfa-2a

    go.drugbank.com/drugs/DB00034
    ApprovedInvestigationalWithdrawn

    Interferon a (human leukocyte protein moiety reduced). A type I interferon consisting of 165 amino acid residues with lysine in position 23.

    Synonyms: SH-polypeptide-46International brands: Roferon A
  9. Drug

    Cocaine

    go.drugbank.com/drugs/DB00907
    ApprovedIllicitInvestigational

    It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. … It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse.

    Synonyms: [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester, methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  10. Drug

    Melatonin

    go.drugbank.com/drugs/DB01065
    ApprovedInvestigationalNutraceuticalVet approved

    Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. … Reduced melatonin production has also been proposed as a likely factor in the significantly higher cancer rates in night workers.

    Synonyms: N-[2-(5-methoxyindol-3-yl)ethyl]acetamide, 5-methoxy-N-acetyl tryptamineInternational brands: Mela-T