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Displaying results 4091 - 4100 of 10000 in total
  1. Drug

    Fluconazole

    go.drugbank.com/drugs/DB00196
    ApprovedInvestigational

    Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. … It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole].

    Mixtures: FLUCONAZOL+SECNIDAZOL 75MG/1000 MG, Fluconazole 4% / Ibuprofen 2% / Itraconazole 1% / Terbinafine HCl 4%Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A Inhibitors
  2. Drug

    Interferon alfa

    go.drugbank.com/drugs/DB05258
    ApprovedInvestigationalWithdrawn

    Interferon alfa contains several naturally occurring IFN-α subtypes and is purified by affinity chromatography. … Multiferon consists of the 6 major subtypes are IFN-α1, IFN-α2, IFN-α8, IFN-α10, IFN-α14 and IFN-α21. Of these, IFN-α2 and IFN-α14 are glycosylated.

    Synonyms: IFN-αCategories: Interferon Type I, Cytochrome P-450 CYP1A2 Inhibitors
  3. Drug

    Pamidronic acid

    go.drugbank.com/drugs/DB00282
    ApprovedInvestigational

    Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid].[A203111] Pamidronic acid was first described in the literature in 1977. … [A203267] The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic acid], [minodronic acid], and [risedronic acid] are becoming

    Products: MENEDRON-L 15 MG IV ENJEKSİYONLUK LİYOFİLİZE TOZ İÇEREN FLAKON (4 FLAKON), Pamidronate Disodium Omega 6 mg/ml
  4. Drug

    Brinzolamide

    go.drugbank.com/drugs/DB01194
    Approved

    [A2051] Brinzolamide was approved by the FDA in 1998 as a standalone product and in 2013 as a combination product with brimonidine tartrate. … [L35310,L35315] In Europe, it was also approved as a combination product with timolol in 2008.[L35320]

    Mixtures: BRINZOLAMIDE E TIMOLOLO EG, BRINZOLAMIDE E TIMOLOLO EGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates
  5. Drug

    Brexpiprazole

    go.drugbank.com/drugs/DB09128
    ApprovedInvestigational

    Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). … It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors.

    Categories: MATE 2 Inhibitors, Cytochrome P-450 SubstratesProducts: REXULTI (BREXPIPRAZOLE) TABLETS 4 MG, REXULTI (BREXPIPRAZOLE) TABLETS 1 MG
  6. Target

    Biliverdin reductase A

    go.drugbank.com/bio_entities/BE0000741
    TargetEnzymeHumans

    Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666,

    Polypeptides: Biliverdin reductase ASynonyms: BVR A
  7. Target

    Apolipoprotein A-II

    go.drugbank.com/bio_entities/BE0000922
    TargetHumans

    May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism

    Polypeptides: Apolipoprotein A-II
  8. Target

    Thromboxane-A synthase

    go.drugbank.com/bio_entities/BE0001893
    TargetHumans

    Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:11097184, PubMed:11297515, PubMed:22735388, … Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same

    Polypeptides: Thromboxane-A synthase
  9. Target

    Alpha-galactosidase A

    go.drugbank.com/bio_entities/BE0002422
    TargetEnzymeHumans

    Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome

    Polypeptides: Alpha-galactosidase ASynonyms: Alpha-D-galactosidase A
  10. Target

    Surface protein A

    go.drugbank.com/bio_entities/BE0002809
    TargetNeisseria meningitidis

    Polypeptides: Surface protein A