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Tiaprofenic acid
go.drugbank.com/drugs/DB01600ApprovedTiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain.
Categories: Non COX-2 selective NSAIDSSynonyms: 2-(5-Benzyl-2-thienyl)propionsäure, 2-(5-Benzoyl-thiophen-2-yl)-propionic acidRibonuclease 4
go.drugbank.com/bio_entities/BE0001924TargetHumansCleaves preferentially after uridine bases (PubMed:3467790). Has antimicrobial activity against uropathogenic E.coli (UPEC) (PubMed:33818125). Probably contributes to urinary tract sterility (PubMed:33818125)
Polypeptides: Ribonuclease 4Synonyms: RNase 4Interleukin-4
go.drugbank.com/bio_entities/BE0003520TargetHumansEngagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6 (PubMed:7721895)
Polypeptides: Interleukin-4Synonyms: IL-4Caspase-4
go.drugbank.com/bio_entities/BE0009964TargetHumansInflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis (PubMed:25119034, PubMed:26375003, PubMed:32109412, PubMed:34671164, PubMed:37001519, PubMed:379937...
Polypeptides: Caspase-4Synonyms: CASP-4Myosin-4
go.drugbank.com/bio_entities/BE0021470TargetHumansMuscle contraction
Polypeptides: Myosin-4Synonyms: Myosin heavy chain 4Bromocriptine
go.drugbank.com/drugs/DB01200ApprovedInvestigationalWithdrawnBromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. … In 1995, the FDA withdrew the approval of bromocriptine mesylate for the prevention of physiological lactation after finding that bromocriptine was not shown to be safe for use.
Categories: Heterocyclic Compounds with 4 or More Rings, P-glycoprotein inhibitorsSynonyms: 2-bromo-α-ergokryptin, 2-bromo-α-ergocryptineRepaglinide
go.drugbank.com/drugs/DB00912ApprovedInvestigationalApproximately 90% of a single orally administered dose is eliminated in feces and 8% in urine. … Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight.
Mixtures: PAREGLIN 1 MG/500 MG FILM KAPLI TABLET, 90 ADET, PAREGLIN 2 MG/500 MG FILM KAPLI TABLET, 90 ADETCategories: Drugs Used in Diabetes, Cytochrome P-450 SubstratesCocaine
go.drugbank.com/drugs/DB00907ApprovedIllicitInvestigationalIt is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. … It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester, methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylatePovidone-iodine
go.drugbank.com/drugs/DB06812ApprovedInvestigationalThis unique complex was discovered in 1955 at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski. … Povidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis.
Mixtures: P-Care MG, Pro-C-Dure 4 KitCategories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-RingKetoconazole
go.drugbank.com/drugs/DB01026ApprovedInvestigationalKetoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections. … [A188054] At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption.
Mixtures: CLINDAMICINA/KETOCONAZOL 100 MG/400MG, Ketoconazole 2% / Niacinamide 4%Categories: P-glycoprotein inhibitors, P-glycoprotein substrates