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Fenofibric acid
go.drugbank.com/drugs/DB13873ApprovedInvestigationalIt works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B, while increasing high-density lipoprotein cholesterol. … [A32038,L12855] Due to its high hydrophilicity and poor absorption profile,[A32038] prodrug ,[fenofibrate], and other conjugated compounds of fenofibric acid, such as choline fenofibrate, have been developed
Categories: Peroxisome Proliferator Receptor alpha AgonistMefenamic acid
go.drugbank.com/drugs/DB00784ApprovedA non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
Products: MEFEN DE 500 MG TABLETAS, MEFENAL TABLETAS DE 500 MG.Etifoxine
go.drugbank.com/drugs/DB08986ApprovedWithdrawnIt does not bind to the benzodiazepine receptor though the effects are similar to that of benzodiazepines. It is more effective than lorazepam as an anxiolytic, and has fewer side effects. … Etifoxine is an anxiolytic and anticonvulsant drug developed by Hoechst in the 1960s. It is used in anxiety disorders and to promote peripheral nerve healing.
XEN-2174
go.drugbank.com/drugs/DB05012ExperimentalNET is the primary mechanism regulating the biological effects of norepinephrine (NE) on the body. … In episodes of pain, inhibition of NET by XEN-2174 elevates the levels of NE leading to the activation of inhibitory pathways preventing pain signals from reaching the brain.
Embusartan
go.drugbank.com/drugs/DB19949ExperimentalThe usage of the INN stem '-sartan' in the name indicates that Embusartan is a angiotensin II receptor antagonist, antihypertensive (non-peptidic).
Categories: Agents Acting on the Renin-Angiotensin System, Angiotensin Receptor AntagonistsEthiodized oil
go.drugbank.com/drugs/DB00965ApprovedInvestigationalThe composition of the oil is comprised of iodine combined with ethyl esters of fatty acids of poppyseed oil. … And although these esters are primarily as ethyl monoiodostearate and ethyl diiodostearate, the actual, specific structure is unknown.
Trandolaprilat
go.drugbank.com/drugs/DB14209ExperimentalThe active metabolite of the prodrug [Trandolapril].
Categories: Agents Acting on the Renin-Angiotensin SystemOleoyl-estrone
go.drugbank.com/drugs/DB04870InvestigationalIt has been shown in animal studies to promote the loss of body fat while maintaining body protein storage, maintaining nitrogen balance. … Body protein loss is an unpleasant effect of fat loss by the restriction of calories, and studies show that this drug appears to avoid this effect.
Synonyms: OEFulvestrant
go.drugbank.com/drugs/DB00947ApprovedInvestigationalIt is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor. … While it is used as monotherapy for the treatment of breast cancers, it is also used in combination with [alpelisib] for the treatment of HR-positive, human epidermal growth factor receptor 2 (HER2)-negative
Categories: Estrogen Receptor Antagonists, Selective Estrogen Receptor ModulatorsSelpercatinib
go.drugbank.com/drugs/DB15685ApprovedInvestigationalIt is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc.[L13604] Selpercatinib is also approved by the European Commission. … Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.