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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
go.drugbank.com/bio_entities/BE0000367TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371, PubMed:32385911, PubMed:33153867). … Complex I functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371)
Synonyms: Complex I-19kD, Complex I-PGIVNADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
go.drugbank.com/bio_entities/BE0000493TargetHumansPlays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (PubMed:30879903 … Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor
Synonyms: Complex I-75kDTranslocation protein SEC62
go.drugbank.com/bio_entities/BE0009211TargetPlasmodium falciparum (isolate 3D7)Synonyms: Secretory complex protein 62Trastuzumab
go.drugbank.com/drugs/DB00072ApprovedInvestigational-2 protein in tumours. … [L14015] It is used as a treatment of human epidermal growth factor receptor (HER)-2+ metastatic breast cancer, where there is a proven amplification of the HER-2 oncogene or over-expression of the HER
Mixtures: PHESGO® 600MG/600MG, PHESGO® 600MG/600MGCategories: HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors, Complex MixturesCapsid protein
go.drugbank.com/bio_entities/BE0010951TargetHepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979)Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin
Synonyms: Core antigen, Core proteinNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
go.drugbank.com/bio_entities/BE0000473TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Synonyms: Complex I-13kD-B, Complex I subunit B13NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
go.drugbank.com/bio_entities/BE0000500TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Synonyms: Complex I-AQDQ, Complex I-18 kDaValsartan
go.drugbank.com/drugs/DB00177ApprovedInvestigational[A174124,A173869] Valsartan was initially approved in 1996 in Europe for the treatment of hypertension in adults. Shortly after, in 1997, this drug was approved in the United States. … [A174124] Valsartan is generally well-tolerated with a side-effect profile superior to that of other antihypertensive drugs.[A174130,A174133]
Mixtures: VALSACOR COMP 160/25MG, VALSACOR COMP 160/25MGCategories: Angiotensin 2 Receptor Blocker, Cytochrome P-450 SubstratesDihydrolipoyl dehydrogenase
go.drugbank.com/bio_entities/BE0002965TargetAzotobacter vinelandiiThe pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Synonyms: E3 component of pyruvate complex