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DNA polymerase epsilon subunit 3
go.drugbank.com/bio_entities/BE0003617TargetHumansDoes not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371) … Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity).
Synonyms: Chromatin accessibility complex 17 kDa proteinBromocriptine
go.drugbank.com/drugs/DB01200ApprovedInvestigationalWithdrawnBromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. … In 1995, the FDA withdrew the approval of bromocriptine mesylate for the prevention of physiological lactation after finding that bromocriptine was not shown to be safe for use.
Products: AA PHARMA BROMOCRIPTINE TABLET 2.5 mgPhospholipid-transporting ATPase IC
go.drugbank.com/bio_entities/BE0011765TransporterHumansCatalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner
Synonyms: P4-ATPase flippase complex alpha subunit ATP8B1Tezacaftor
go.drugbank.com/drugs/DB11712ApprovedInvestigational[L1595] It was developed by Vertex Pharmaceuticals and FDA approved in combination with [ivacaftor] to manage cystic fibrosis.[L6814] This drug was approved by the FDA on February 12, 2018. … Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) corrector class.
Insulin icodec
go.drugbank.com/drugs/DB16693ApprovedInvestigationalIt is a re-engineered version of the ultra long-acting oral basal insulin OI338, with several modifications introduced to significantly extend the half-life. … [L51078] In July 2024, the US FDA rejected the approval of insulin icodec, citing concerns regarding hypoglycemia and the indication being sought for type 1 diabetes mellitus.
Cholestyramine
go.drugbank.com/drugs/DB01432ApprovedInvestigationalCholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins.
Categories: Compounds used in a research, industrial, or household settingProducts: COLESTYRAMIN 1A PHARMA 4GAmmonia
go.drugbank.com/drugs/DB11118ApprovedInvestigationalIt is a colorless gas with a pungent smell, and become NH4, or ammonium ion, when in water. … Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry.
Carbazochrome
go.drugbank.com/drugs/DB09012ApprovedWithdrawneither at a local or systemic level [A19744]. … It is not FDA-approved but is available as tablets or IM/SC injections in the treatment of hemorrhages in a number of countries.
International brands: Di Ka Ning, Ge DanBelzutifan
go.drugbank.com/drugs/DB15463ApprovedInvestigational[L36105] Belzutifan inhibits the complexation of HIF-2α with another transcription factor, HIF-1β, a necessary step in its activation - by preventing the formation of this complex, belzutifan can slow … Belzutifan received FDA approval for the treatment of select VHL-associated cancers on August 13, 2021.
Methionine
go.drugbank.com/drugs/DB00134ApprovedInvestigationalNutraceuticalA sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.
Mixtures: SOLUCION DP-AMINE, AA-VenSynonyms: L-a-Amino-g-methylthiobutyric acid