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Displaying results 4191 - 4200 of 10000 in total
  1. Target

    Cyclic nucleotide phosphodiesterase

    go.drugbank.com/bio_entities/BE0004922
    TargetHumans

    Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447). … The catalytic site can adopt partially open conformations even in the inhibited state, contributing to the higher basal activity and rapid response kinetics characteristic of cones compared to rods (PubMed

    Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10ASynonyms: cAMP and cGMP phosphodiesterase 11A, Cam-PDE 1A
  2. Indication

    Hearth Failure With Reduced Ejection Fraction (HFrEF)

    go.drugbank.com/conditions/DBCOND0080197
    Drugs: Ramipril
    Synonyms: Heart Failure and Reduced Ejection Fraction
  3. Indication

    Seasonal Allergic Rhinitis

    go.drugbank.com/conditions/DBCOND0030588
    Drugs: Acrivastine · Azelastine · Beclomethasone dipropionate · Bilastine · Cetirizine · Ciclesonide +22 more
    Synonyms: Vasomotor and allergic rhinitis
  4. Indication

    Temporomandibular Joint Dysfunction

    go.drugbank.com/conditions/DBCOND0039544
    Drugs: Botulinum toxin type A
    Synonyms: Temporomandibular pain and dysfunction syndrome
  5. Drug

    Influenza B virus B/Maryland/15/2016 antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB14591
    ApprovedWithdrawn

    Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen … Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals.

    Mixtures: SKYCellflu Trivalent Solution for Injection in Prefilled Syringe 0.25ml, SKYCellflu Trivalent Solution for Injection in Prefilled Syringe 0.5ml
  6. Drug

    Invert sugar

    go.drugbank.com/drugs/DB09344
    Experimental

    Invert sugar is obtained from sugar cane when this is treated with dilute acid or with the invertase enzyme. It is formed by an equal amount of glucose and fructose. … It differentiates from sugar cane in the rotation of the polarized light, which in the case of invert sugar it is to the left (levorotatory).

    Categories: Diet, Food, and Nutrition, Compounds used in a research, industrial, or household setting
  7. Drug

    Mobocertinib

    go.drugbank.com/drugs/DB16390
    ApprovedInvestigationalWithdrawn

    [A238828] Mobocertinib appears to be an effective means of treating this otherwise treatment-resistant NSCLC, exerting an inhibitory effect on _EGFR_ exon 20 insertion mutant variants at concentrations … It is used specifically in the treatment of non-small cell lung cancer (NSCLC) caused by exon 20 insertion mutations in the _EGFR_ gene,[L38368] which are typically associated with a poorer prognosis (

    Categories: Antineoplastic and Immunomodulating Agents
  8. Drug

    Medifoxamine

    go.drugbank.com/drugs/DB13219
    Approved

    Medifoxamine was marketed as an atypical antidepressant, with anxiolyitc properties in France, Spain, and Morrocco in the 1990s but was later withdrawn from the market due to it causing cases of hepatotoxicity

  9. Drug

    Asparagine

    go.drugbank.com/drugs/DB00174
    ApprovedNutraceuticalWithdrawn

    A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from aspartic acid and ammonia by asparagine synthetase. … (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

    Categories: Amino Acids, Peptides, and Proteins
  10. Drug

    Dihydrotachysterol

    go.drugbank.com/drugs/DB01070
    ApprovedWithdrawn

    A vitamin D that can be regarded as a reduction product of vitamin D2.

    Categories: Diet, Food, and Nutrition, Vitamin D and Analogues