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Splicing factor, proline- and glutamine-rich
go.drugbank.com/bio_entities/BE0008965TargetHumansPlays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune … The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity.
Synonyms: DNA-binding p52/p100 complex, 100 kDa subunitInter-alpha-trypsin inhibitor heavy chain H2
go.drugbank.com/bio_entities/BE0009060TargetHumansMay act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are ...
Synonyms: Inter-alpha-trypsin inhibitor complex component IIInter-alpha-trypsin inhibitor heavy chain H1
go.drugbank.com/bio_entities/BE0009080TargetEnzymeHumansMay act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are ...
Synonyms: Inter-alpha-trypsin inhibitor complex component IIIGenistein
go.drugbank.com/drugs/DB01645InvestigationalIt inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. … Further, genistein is a phytoestrogen which has selective estrogen receptor modulator properties.
Mirvetuximab soravtansine
go.drugbank.com/drugs/DB12489ApprovedInvestigational[A254382] After an ADC/receptor complex is formed, mirvetuximab soravtansine-gynx is internalized, and DM4 is released inside the cell. … linker to the genotoxic compound DM4 (also known as soravtansine or ravtansine).
Invert sugar
go.drugbank.com/drugs/DB09344Experimental[A32124] Invert sugar is FDA approved since 1988 as a safe substance (GRAS). … Invert sugar is obtained from sugar cane when this is treated with dilute acid or with the invertase enzyme. It is formed by an equal amount of glucose and fructose.
Proteasome subunit alpha type-6
go.drugbank.com/bio_entities/BE0003915TargetHumansComponent of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Synonyms: Multicatalytic endopeptidase complex iota chainGlycerol phenylbutyrate
go.drugbank.com/drugs/DB08909ApprovedInvestigationalGlycerol phenylbutyrate is a nitrogen-binding agent. Chemically, it is a triglyceride in which three molecules of phenylbutyrate are linked to a glycerol backbone. FDA approved on February 1, 2013.
Tocilizumab
go.drugbank.com/drugs/DB06273ApprovedInvestigationalTyenne is the first tocilizumab biosimilar approved in both intravenous and subcutaneous formulations and is authorized to treat several inflammatory conditions, including rheumatoid arthritis and juvenile … Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions.
Bacillus calmette-guerin substrain russian BCG-I live antigen
go.drugbank.com/drugs/DB16648ApprovedInvestigationalIt was developed to alleviate Canada's multi-year shortage of BCG vaccine, and is expected to be available by mid-2021.[L32734] … [L32734] It is to be marketed by Verity Pharmaceuticals, under the trade name VERITY-BCG, and manufactured by the Serum Institute of India.