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Displaying results 4201 - 4210 of 10000 in total
  1. Drug

    Enalapril

    go.drugbank.com/drugs/DB00584
    ApprovedInvestigationalVet approved

    It is also found in a combination product containing [hydrochlorothiazide] that is used for the management of hypertension. … It was developed from a targeted research programmed using molecular modelling.

    Mixtures: DUOPRES® 5 MG / 20 MG CÁPSULAS, DUOPRES ® 5 MG / 10 MG CÁPSULASCategories: P-glycoprotein inhibitors, Agents Acting on the Renin-Angiotensin System
  2. Drug

    Ceftazidime

    go.drugbank.com/drugs/DB00438
    ApprovedInvestigational

    [L32935] Ceftazidime was approved by the FDA on July 19, 1985, and is currently available either alone or in combination with the non-β-lactam β-lactamase inhibitor [avibactam] to treat a variety of … Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding

    Mixtures: CEFAZIME FOR INJECTION 1 g/vial, ZAVİCEFTA 2 G/0.5 G İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN TOZ, 10 ADETCategories: Heterocyclic Compounds, 2-Ring
  3. Drug

    Tavolixizumab

    go.drugbank.com/drugs/DB15042
    Investigational

    Tavolixizumab is under investigation in clinical trial NCT02318394 (A Phase 1 Study of MEDI0562 in Adult Subjects With Selected Advanced Solid Tumors).

    Synonyms: IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENSTNFRSF4 (TUMOR NECROSIS FACTOR RECEPTOR (TNFR) SUPERFAMILY MEMBER 4, OX40, CD134)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY GAMMA1 HEAVY CHAIN (1-451) (CHIMERIC, VH (MUS MUSCULUS IGHV3-8*02 -(IGHD)-HOMO SAPIEN
  4. Drug

    Omeprazole

    go.drugbank.com/drugs/DB00338
    ApprovedInvestigationalVet approved

    Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. … Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].

    Mixtures: ORAZOLE ® 10 MG CAPSULA, OMEPRAZOL 20 MGCategories: P-glycoprotein inhibitors, P-glycoprotein substrates
  5. Target

    Cholecystokinin receptor type A

    go.drugbank.com/bio_entities/BE0000402
    TargetHumans

    This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system … Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system.

    Polypeptides: Cholecystokinin receptor type ASynonyms: CCK-A receptor
  6. Target

    Choline-phosphate cytidylyltransferase A

    go.drugbank.com/bio_entities/BE0000615
    EnzymeTargetHumans

    Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis

    Polypeptides: Choline-phosphate cytidylyltransferase ASynonyms: CT A, CCT A
  7. Target

    Catabolite control protein A

    go.drugbank.com/bio_entities/BE0001530
    TargetBacillus megaterium

    Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.

    Polypeptides: Catabolite control protein A
  8. Target

    Fructose-bisphosphate aldolase A

    go.drugbank.com/bio_entities/BE0001683
    TargetEnzymeHumans

    In addition, also functions as a scaffolding protein (By similarity). … Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013).

    Polypeptides: Fructose-bisphosphate aldolase A
  9. Target

    Outer membrane protein A

    go.drugbank.com/bio_entities/BE0002043
    TargetEscherichia coli (strain K12)

    Plays a role in resistance to environmental stress, and a role in outer membrane functionality and cell shape (PubMed:11906175, PubMed:361695). … A very abundant protein, there can be up to 210,000 OmpA molecules per cell (PubMed:24766808).

    Polypeptides: Outer membrane protein ASynonyms: Outer membrane porin A
  10. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0003724
    TargetStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.

    Polypeptides: DNA gyrase subunit A